Decades of research in skeletal muscle physiology have provided multiscale insights into
the structural and functional complexity of this important anatomical tissue, designed to …

Mounting evidence suggests that acute and chronic stress, especially the stress-induced
release of glucocorticoids, induces changes in glutamate neurotransmission in the prefrontal …

Abstract α-Synuclein is a neuronal protein that is enriched in presynaptic terminals. Under
physiological conditions, it binds to synaptic vesicle membranes and functions in …

Synaptic transmission is mediated by neurotransmitters that are stored in synaptic vesicles
and released by exocytosis upon activation. The vesicle membrane is then retrieved by …

Chemical synapses are the predominant neuron-to-neuron contact in the central nervous
system. Presynaptic boutons of neurons contain hundreds of vesicles filled with …

In the cerebral cortex, local circuits consist of tens of thousands of neurons, each of which
makes thousands of synaptic connections. Perhaps the biggest impediment to …

Synapse regulation exploits the capacity of actin to function as a stable structural component
or as a dynamic filament. Beyond its well-appreciated role in eliciting visible morphological …

We present video-rate (28 frames per second) far-field optical imaging with a focal spot size
of 62 nanometers in living cells. Fluorescently labeled synaptic vesicles inside the axons of …

In a forward screen for genes affecting neurotransmission in Drosophila, we identified
mutations in dynamin-related protein (drp1). DRP1 is required for proper cellular distribution …

Emerging evidence indicates that liquid–liquid phase separation, the formation of a
condensed molecular assembly within another diluted aqueous solution, is a means for cells …