Basal forebrain cholinergic signalling: development, connectivity and roles in cognition

MR Ananth, P Rajebhosale, R Kim… - Nature Reviews …, 2023 - nature.com
Acetylcholine plays an essential role in fundamental aspects of cognition. Studies that have
mapped the activity and functional connectivity of cholinergic neurons have shown that the …

Salvia (Sage): A review of its potential cognitive-enhancing and protective effects

AL Lopresti - Drugs in R&D, 2017 - Springer
Genus Salvia, commonly known as sage, is the largest genus in the Lamiaceae family. It
comprises many species traditionally used as brain-enhancing tonics. In vitro and animal …

Fast and slow: Recording neuromodulator dynamics across both transient and chronic time scales

P Ma, P Chen, EI Tilden, S Aggarwal, A Oldenborg… - Science …, 2024 - science.org
Neuromodulators transform animal behaviors. Recent research has demonstrated the
importance of both sustained and transient change in neuromodulators, likely due to tonic …

Cellular mechanisms of brain state–dependent gain modulation in visual cortex

PO Polack, J Friedman, P Golshani - Nature neuroscience, 2013 - nature.com
Visual cortical neurons fire at higher rates to visual stimuli during locomotion than during
immobility, while maintaining orientation selectivity. The mechanisms underlying this change …

Cholinergic modulation of glial function during aging and chronic neuroinflammation

R Gamage, I Wagnon, I Rossetti, R Childs… - Frontiers in Cellular …, 2020 - frontiersin.org
Aging is a complex biological process that increases the risk of age-related cognitive
degenerative diseases such as dementia, including Alzheimer's disease (AD), Lewy Body …

[HTML][HTML] Cholinergic modulation of cognitive processing: insights drawn from computational models

EL Newman, K Gupta, JR Climer… - Frontiers in behavioral …, 2012 - frontiersin.org
Acetylcholine plays an important role in cognitive function, as shown by pharmacological
manipulations that impact working memory, attention, episodic memory, and spatial memory …

Age differences in the Attention Network Test: Evidence from behavior and event-related potentials

RS Williams, AL Biel, P Wegier, LK Lapp, BJ Dyson… - Brain and …, 2016 - Elsevier
Abstract The Attention Network Test (ANT) is widely used to capture group and individual
differences in selective attention. Prior behavioral studies with younger and older adults …

Cholinergic modulation of the medial prefrontal cortex: the role of nicotinic receptors in attention and regulation of neuronal activity

B Bloem, RB Poorthuis, HD Mansvelder - Frontiers in neural circuits, 2014 - frontiersin.org
Acetylcholine (ACh) release in the medial prefrontal cortex (mPFC) is crucial for normal
cognitive performance. Despite the fact that many have studied how ACh affects neuronal …

Role of the locus coeruleus and basal forebrain in arousal and attention

EB Maness, JA Burk, JT McKenna, FL Schiffino… - Brain Research …, 2022 - Elsevier
Experimental evidence has implicated multiple neurotransmitter systems in either the direct
or indirect modulation of cortical arousal and attention circuitry. In this review, we selectively …

Topographic map** between basal forebrain cholinergic neurons and the medial prefrontal cortex in mice

B Bloem, L Schoppink, DC Rotaru, A Faiz… - Journal of …, 2014 - jneurosci.org
The basal forebrain cholinergic innervation of the medial prefrontal cortex (mPFC) is crucial
for cognitive performance. However, little is known about the organization of connectivity …