Malaria parasites break down host haemoglobin into peptides and amino acids in the
digestive vacuole for export to the parasite cytoplasm for growth: interrupting this process is …

The global spread of sulfadoxine (Sdx, S) and pyrimethamine (Pyr, P) resistance is attributed
to increasing number of mutations in DHPS and DHFR enzymes encoded by malaria …

Molecular approaches have an increasingly recognized utility in surveillance of malaria
parasite populations, not only in defining prevalence and incidence with higher sensitivity …

MalariaGEN is a data-sharing network that enables groups around the world to work
together on the genomic epidemiology of malaria. Here we describe a new release of …

Malaria results in over 600,000 deaths annually, with the highest burden of deaths in young
children living in sub-Saharan Africa. Molecular surveillance can provide important …

Abstract Background Drug resistance in Plasmodium falciparum is a major threat to malaria
control efforts. Pathogen genomic surveillance could be invaluable for monitoring current …

Locally varying selection on pathogens may be due to differences in drug pressure, host
immunity, transmission opportunities between hosts, or the intensity of between-genotype …

Identification of genomic regions that are identical by descent (IBD) has proven useful for
human genetic studies where analyses have led to the discovery of familial relatedness and …

Malaria cases caused by the zoonotic parasite Plasmodium knowlesi are being increasingly
reported throughout Southeast Asia and in travelers returning from the region. To test for …

Genome sequences of 247 Plasmodium falciparum isolates collected in The Gambia in
2008 and 2014 were analysed to identify changes possibly related to the scale-up of …