Chemical and pharmacological aspects of caffeic acid and its activity in hepatocarcinoma

KMM Espíndola, RG Ferreira, LEM Narvaez… - Frontiers in …, 2019 - frontiersin.org
Caffeic acid (CA) is a phenolic compound synthesized by all plant species and is present in
foods such as coffee, wine, tea, and popular medicines such as propolis. This phenolic acid …

[HTML][HTML] IL-6 pathway in the liver: from physiopathology to therapy

D Schmidt-Arras, S Rose-John - Journal of hepatology, 2016 - Elsevier
Summary Interleukin 6 (IL-6) is a pleiotropic four-helix-bundle cytokine that exerts multiple
functions in the body. In the liver, IL-6 is an important inducer of the acute phase response …

The role of interleukin 6 during viral infections

L Velazquez-Salinas, A Verdugo-Rodriguez… - Frontiers in …, 2019 - frontiersin.org
Our recently published research on the characterization of vesicular stomatitis virus (VSV)
pathogenesis in swine, identified a systemic upregulation of interleukin 6 (IL-6) during the …

The role of IL-6 in host defence against infections: immunobiology and clinical implications

S Rose-John, K Winthrop, L Calabrese - Nature Reviews Rheumatology, 2017 - nature.com
IL-6 is a pleiotropic cytokine with broad-ranging effects within the integrated immune
response. One of the roles of IL-6 is to support immunocompetence, defined as the ability of …

Circulating and intrahepatic antiviral B cells are defective in hepatitis B

AR Burton, LJ Pallett, LE McCoy… - The Journal of …, 2018 - Am Soc Clin Investig
B cells are increasingly recognized as playing an important role in the ongoing control of
hepatitis B virus (HBV). The development of antibodies against the viral surface antigen …

NF-κB in the liver—linking injury, fibrosis and hepatocellular carcinoma

T Luedde, RF Schwabe - Nature reviews Gastroenterology & …, 2011 - nature.com
Hepatic cirrhosis and hepatocellular carcinoma (HCC) are the most common causes of
death in patients with chronic liver disease. Chronic liver injury of virtually any etiology …

Hepatitis B virus infection

MF Yuen, DS Chen, GM Dusheiko… - Nature reviews Disease …, 2018 - nature.com
Hepatitis B virus (HBV) is a hepatotropic virus that can establish a persistent and chronic
infection in humans through immune anergy. Currently, 3.5% of the global population is …

Living in the liver: hepatic infections

U Protzer, MK Maini, PA Knolle - Nature Reviews Immunology, 2012 - nature.com
The liver has vital metabolic and clearance functions that involve the uptake of nutrients,
waste products and pathogens from the blood. In addition, its unique immunoregulatory …

Republished: Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection

A Bertoletti, C Ferrari - Postgraduate Medical Journal, 2013 - academic.oup.com
Abstract Knowledge of the immunological events necessary to control hepatitis B virus
(HBV) infection has accelerated in recent years, but their translation towards therapeutic …

3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection

AM Ortega-Prieto, JK Skelton, SN Wai, E Large… - Nature …, 2018 - nature.com
With more than 240 million people infected, hepatitis B virus (HBV) is a major health
concern. The inability to mimic the complexity of the liver using cell lines and regular primary …