Less is more: Exploring neoadjuvant immunotherapy as a de-escalation strategy in head and neck squamous cell carcinoma treatment

LM Cao, NN Zhong, Y Chen, ZZ Li, GR Wang, Y **ao… - Cancer Letters, 2024 - Elsevier
Head and neck squamous cell carcinoma (HNSCC) constitutes a significant global cancer
burden, given its high prevalence and associated mortality. Despite substantial progress in …

Surgical and safety outcomes in patients with non-small cell lung cancer receiving neoadjuvant chemoimmunotherapy versus chemotherapy alone: A systematic …

R Aburaki, Y Fujiwara, K Chida, N Horita… - Cancer treatment …, 2024 - Elsevier
Neoadjuvant immune checkpoint blockade (ICB) combined with chemotherapy has
improved survival outcomes in locally-advanced non-small cell lung cancer (NSCLC) …

Treatment-related adverse events, including fatal toxicities, in patients with extensive-stage small-cell lung cancer receiving adjuvant programmed cell death 1 …

FCA de Moraes, A de OM Lôbo, VKT Sano, FA Kelly… - Clinical Oncology, 2024 - Elsevier
Abstract Background/Aims The safety profile of programmed cell death 1 (PD-
1)/programmed cell death ligand 1 (PD-L1) inhibitors when associated with chemotherapy …

Endocrine adverse events in patients with cancer receiving perioperative immune checkpoint blockade: a meta-analysis of randomized controlled trials

S Zhou, N Horita, T Shao… - … Advances in Medical …, 2024 - journals.sagepub.com
Background: Perioperative use of immune checkpoint blockade (ICB) improves survival in
patients with early-stage cancer. Treatment-related adverse events (AEs), frequently involve …

Neoadjuvant chemoimmunotherapy complicates subsequent surgical resection and adjuvant immunotherapy is preferable from the surgical standpoint

PU Figueroa, V Lacroix, PE Van Schil - Journal of Thoracic Oncology, 2024 - Elsevier
In April 2022, Forde et al. 1 published the CheckMate 816 trial, the first ever phase 3 trial
reporting that neoadjuvant chemotherapy plus nivolumab followed by surgery offered …

Toxicity of immune checkpoint inhibitors and tyrosine kinase inhibitor combinations in solid tumours: a systematic review and meta-analysis

D O'Reilly, CL O'Leary, A Reilly, MY Teo… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
The combination of immune checkpoint inhibitors (ICIs) and tyrosine kinase inhibitors (TKIs)
can be associated with significant toxicity. We performed a systematic review and meta …

[HTML][HTML] A novel HVEM-Fc recombinant protein for lung cancer immunotherapy

Y Yao, B Li, J Wang, C Chen… - Journal of Experimental …, 2025 - pmc.ncbi.nlm.nih.gov
Background The ubiquitously expressed transmembrane protein, Herpesvirus Entry
Mediator (HVEM), functions as a molecular switch, capable of both activating and inhibiting …

Improved event-free survival after complete or major pathologic response in patients with resectable NSCLC treated with neoadjuvant chemoimmunotherapy …

D Marinelli, A Nuccio, A Di Federico, F Ambrosi… - Journal of Thoracic …, 2024 - Elsevier
Background Neoadjuvant chemoimmunotherapy has reshaped the treatment landscape for
resectable NSCLC, yet the prognostic significance of pathologic response remains unclear …

Toxicity profiles of immunochemotherapy for gastric or gastroesophageal junction adenocarcinoma: a systematic review and meta-analysis

L Wan, F Tian, L Wang, Y Hou, W Liu, Q Liu, D Chen… - Cellular Oncology, 2024 - Springer
Purpose Neoadjuvant immunochemotherapy is emerging as a promising regimen for
patients with locally advanced gastric and gastroesophageal junction (G/GEJ) …

Real-world evidence on efficacy and toxicity of targeted therapy in older melanoma patients treated in a tertiary-hospital setting

R Stoff, SN Markovic, RR McWilliams… - Melanoma …, 2024 - journals.lww.com
Melanoma is the deadliest form of skin cancer. The median age at diagnosis is 66. While
most patients are treated with immunotherapy, the use of targeted therapy is a valid …