The main goal of chemotherapeutic drugs is to induce massive cell death in tumors.
Cisplatin is an antitumor drug widely used to treat several types of cancer. Despite its …

The repair of DNA damage is a complex process that relies on particular pathways to
remedy specific types of damage to DNA. The range of insults to DNA includes small …

Molecular mechanics Poisson–Boltzmann surface area (MM-PBSA), a method to estimate
interaction free energies, has been increasingly used in the study of biomolecular …

Cisplatin is a chemotherapeutic drug used for the treatment of a number of cancers. The
efficacy of cisplatin relies on its binding to DNA and the induction of cytotoxic DNA damage …

Disruptions in DNA repair pathways predispose cells to accumulating DNA damage. A
growing body of evidence indicates that tumors accumulate progressively more mutations in …

Over the course of long-term evolution, cells have developed intricate defense mechanisms
in response to DNA damage; these mechanisms play a pivotal role in maintaining genomic …

Toluene and its derivatives are petroleum-derived raw materials produced from gasoline by
catalytic reformation. These abundant chemical feedstocks are commonly used as solvents …

Cancer cells are often characterized by abnormalities in DNA damage response including
defects in cell cycle checkpoints and/or DNA repair. Synthetic lethality between DNA …

The nucleotide excision repair (NER) pathway is activated in response to a broad spectrum
of DNA lesions, including bulky lesions induced by platinum-based chemotherapeutic …

DNA damage response, a key factor involved in maintaining genome integrity and stability,
consists of several kinase-dependent signaling pathways, which sense and transduce DNA …