In humans, nearly two meters of genomic material must be folded to fit inside each
micrometer-scale cell nucleus while remaining accessible for gene transcription, DNA …

Across the expanse of vertebrate evolution, each species produces multiple forms of
hemoglobin in erythroid cells at appropriate times and in the proper amounts. The multiple …

Conformation capture technologies (eg, Hi-C) chart physical interactions between chromatin
regions on a genome-wide scale. However, the structural variability of the genome between …

Complex-systems describe multiple levels of collective structure and organization. In such
systems, the emergence of global behaviour from local interactions is generally studied …

Background Genome structures are dynamic and non-randomly organized in the nucleus of
higher eukaryotes. To maximize the accuracy and coverage of three-dimensional genome …

Abstract The three-dimensional (3D) organization of chromosomes can be probed using
methods like Capture-C. However, it is unclear how such population-level data relate to the …

Chromosome conformation capture technologies such as Hi-C are widely used to
investigate the spatial organization of genomes. Because genome structures can vary …

Background Insulators play a central role in gene regulation, chromosomal architecture and
genome function in higher eukaryotes. To learn more about how insulators carry out their …

Restraint-based modeling of genomes has been recently explored with the advent of
Chromosome Conformation Capture (3C-based) experiments. We previously developed a …

Chromatin remodeling impacts the structural neighborhoods and regulates gene
expression. However, the role of enhancer-guided chromatin remodeling in the gene …