Membrane recognition by phospholipid-binding domains
Many different globular domains bind to the surfaces of cellular membranes, or to specific
phospholipid components in these membranes, and this binding is often tightly regulated …
phospholipid components in these membranes, and this binding is often tightly regulated …
The inositol phosphate signalling network in physiology and disease
Combinatorial substitution of phosphate groups on the inositol ring gives rise to a plethora of
inositol phosphates (InsPs) and inositol pyrophosphates (PP-InsPs). These small molecules …
inositol phosphates (InsPs) and inositol pyrophosphates (PP-InsPs). These small molecules …
[HTML][HTML] Molecular choreography of acute exercise
Acute physical activity leads to several changes in metabolic, cardiovascular, and immune
pathways. Although studies have examined selected changes in these pathways, the system …
pathways. Although studies have examined selected changes in these pathways, the system …
T-cell signaling regulated by the Tec family kinase, Itk
The Tec family tyrosine kinases regulate lymphocyte development, activation, and
differentiation. In T cells, the predominant Tec kinase is Itk, which functions downstream of …
differentiation. In T cells, the predominant Tec kinase is Itk, which functions downstream of …
Inositol pyrophosphates as mammalian cell signals
Inositol pyrophosphates are highly energetic inositol polyphosphate molecules present in
organisms from slime molds and yeast to mammals. Distinct classes of enzymes generate …
organisms from slime molds and yeast to mammals. Distinct classes of enzymes generate …
Themis sets the signal threshold for positive and negative selection in T-cell development
Abstract Development of a self-tolerant T-cell receptor (TCR) repertoire with the potential to
recognize the universe of infectious agents depends on proper regulation of TCR signalling …
recognize the universe of infectious agents depends on proper regulation of TCR signalling …
Themis controls thymocyte selection through regulation of T cell antigen receptor–mediated signaling
G Fu, S Vallée, V Rybakin, MV McGuire, J Ampudia… - Nature …, 2009 - nature.com
Themis (thymocyte-expressed molecule involved in selection), a member of a family of
proteins with unknown functions, is highly conserved among vertebrates. Here we found that …
proteins with unknown functions, is highly conserved among vertebrates. Here we found that …
Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate
Bruton's tyrosine kinase (Btk), a Tec-family tyrosine kinase, is essential for B-cell function.
We present crystallographic and biochemical analyses of Btk, which together reveal …
We present crystallographic and biochemical analyses of Btk, which together reveal …
Diphosphoinositol polyphosphates: metabolic messengers?
SB Shears - Molecular pharmacology, 2009 - Elsevier
The diphosphoinositol polyphosphates (“inositol pyrophosphates”) are a specialized
subgroup of the inositol phosphate signaling family. This review proposes that many of the …
subgroup of the inositol phosphate signaling family. This review proposes that many of the …
Loss-of-function mutations within the IL-2 inducible kinase ITK in patients with EBV-associated lymphoproliferative diseases
RM Linka, SL Risse, K Bienemann, M Werner, Y Linka… - Leukemia, 2012 - nature.com
The purpose of this study was the appraisal of the clinical and functional consequences of
germline mutations within the gene for the IL-2 inducible T-cell kinase, ITK. Among patients …
germline mutations within the gene for the IL-2 inducible T-cell kinase, ITK. Among patients …