Applications of network pharmacology in traditional Chinese medicine research
Z Zhou, B Chen, S Chen, M Lin, Y Chen… - Evidence‐Based …, 2020 - Wiley Online Library
Human diseases, especially infectious ones, have been evolving constantly. However, their
treatment strategies are not develo** quickly. Some diseases are caused by a variety of …
treatment strategies are not develo** quickly. Some diseases are caused by a variety of …
Identifying compound efficacy targets in phenotypic drug discovery
Highlights•Compound target ID technologies have unique strengths that can be used
strategically.•Target ID approaches are trending toward unbiased, genome-wide …
strategically.•Target ID approaches are trending toward unbiased, genome-wide …
Activity, assay and target data curation and quality in the ChEMBL database
The emergence of a number of publicly available bioactivity databases, such as ChEMBL,
PubChem BioAssay and BindingDB, has raised awareness about the topics of data curation …
PubChem BioAssay and BindingDB, has raised awareness about the topics of data curation …
Chinese medicine in the treatment of non-alcoholic fatty liver disease based on network pharmacology: a review
S Zheng, C Xue, S Li, X Zao, X Li, Q Liu… - Frontiers in …, 2024 - frontiersin.org
Non-alcoholic fatty liver disease (NAFLD) is a clinicopathological syndrome characterized
by abnormalities in hepatic fat deposition, the incidence of which has been increasing year …
by abnormalities in hepatic fat deposition, the incidence of which has been increasing year …
Open source Bayesian models. 1. Application to ADME/Tox and drug discovery datasets
On the order of hundreds of absorption, distribution, metabolism, excretion, and toxicity
(ADME/Tox) models have been described in the literature in the past decade which are …
(ADME/Tox) models have been described in the literature in the past decade which are …
Artificial intelligence and machine-learning approaches in structure and ligand-based discovery of drugs affecting central nervous system
CNS disorders are indications with a very high unmet medical needs, relatively smaller
number of available drugs, and a subpar satisfaction level among patients and caregiver …
number of available drugs, and a subpar satisfaction level among patients and caregiver …
Network pharmacology-based approaches capture essence of Chinese herbal medicines
Y Zhang, X Mao, Q Guo, N Lin, S Li - Chinese Herbal Medicines, 2016 - Elsevier
Abstract Traditional Chinese Medicine (TCM), a crucial component of the current medical
system, has been extensively used in clinical practice due to its valuable therapeutic …
system, has been extensively used in clinical practice due to its valuable therapeutic …
Understanding membrane protein drug targets in computational perspective
J Gong, Y Chen, F Pu, P Sun, F He, L Zhang… - Current Drug …, 2019 - ingentaconnect.com
Membrane proteins play crucial physiological roles in vivo and are the major category of
drug targets for pharmaceuticals. The research on membrane protein is a significant part in …
drug targets for pharmaceuticals. The research on membrane protein is a significant part in …
Open source Bayesian models. 2. Mining a “big dataset” to create and validate models with ChEMBL
In an associated paper, we have described a reference implementation of Laplacian-
corrected naïve Bayesian model building using extended connectivity (ECFP)-and …
corrected naïve Bayesian model building using extended connectivity (ECFP)-and …
[HTML][HTML] Protoplast Isolation and Shoot Regeneration from Protoplast-Derived Callus of Petunia hybrida Cv. Mirage Rose
Despite the increasing use of protoplasts in plant biotechnology research, shoot
regeneration from protoplasts remains challenging. In this study, we investigated the factors …
regeneration from protoplasts remains challenging. In this study, we investigated the factors …