Current state and future directions in the therapy of ALS
L Tzeplaeff, S Wilfling, MV Requardt, M Herdick - Cells, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder
affecting upper and lower motor neurons, with death resulting mainly from respiratory failure …
affecting upper and lower motor neurons, with death resulting mainly from respiratory failure …
[HTML][HTML] Amyotrophic Lateral Sclerosis: Insights and New Prospects in Disease Pathophysiology, Biomarkers and Therapies
Amyotrophic Lateral Sclerosis (ALS) is a severe neurodegenerative disorder marked by the
gradual loss of motor neurons, leading to significant disability and eventual death. Despite …
gradual loss of motor neurons, leading to significant disability and eventual death. Despite …
Intrathecal pseudodelivery of drugs in the therapy of neurodegenerative diseases: rationale, basis and potential applications
Intrathecal pseudodelivery of drugs is a novel route to administer medications to treat
neurodegenerative diseases based on the CSF-sink therapeutic strategy by means of …
neurodegenerative diseases based on the CSF-sink therapeutic strategy by means of …
Characterization of Molecular Tweezer Binding on α-Synuclein with Native Top-Down Mass Spectrometry and Ion Mobility-Mass Spectrometry Reveals a Mechanism …
C Lantz, J Lopez, AK Goring… - Journal of the …, 2023 - ACS Publications
Parkinson's disease, a neurodegenerative disease that affects 15 million people worldwide,
is characterized by deposition of α-synuclein into Lewy Bodies in brain neurons. Although …
is characterized by deposition of α-synuclein into Lewy Bodies in brain neurons. Although …
Unraveling the multifaceted insights into amyotrophic lateral sclerosis: Genetic underpinnings, pathogenesis, and therapeutic horizons
Abstract Amyotrophic Lateral Sclerosis (ALS), a progressive neurodegenerative disease,
primarily impairs upper and lower motor neurons, leading to debilitating motor dysfunction …
primarily impairs upper and lower motor neurons, leading to debilitating motor dysfunction …
[HTML][HTML] Pathological Involvement of Protein Phase Separation and Aggregation in Neurodegenerative Diseases
Y Wu, B Ma, C Liu, D Li, G Sui - International Journal of Molecular …, 2024 - mdpi.com
Neurodegenerative diseases are the leading cause of human disability and immensely
reduce patients' life span and quality. The diseases are characterized by the functional loss …
reduce patients' life span and quality. The diseases are characterized by the functional loss …
Intracellular spatially-targeted chemical chaperones increase native state stability of mutant SOD1 barrel
Amyotrophic lateral sclerosis (ALS) is a progressive neurological disorder with currently no
cure. Central to the cellular dysfunction associated with this fatal proteinopathy is the …
cure. Central to the cellular dysfunction associated with this fatal proteinopathy is the …
Protein aggregation and therapeutic strategies in SOD1-and TDP-43-linked ALS
M Tsekrekou, M Giannakou… - Frontiers in Molecular …, 2024 - frontiersin.org
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with severe socio-
economic impact. A hallmark of ALS pathology is the presence of aberrant cytoplasmic …
economic impact. A hallmark of ALS pathology is the presence of aberrant cytoplasmic …
[PDF][PDF] Current State and Future Directions in the Therapy of ALS. Cells 2023, 12, 1523
L Tzeplaeff, S Wilfling, MV Requardt, M Herdick - 2023 - pdfs.semanticscholar.org
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder
affecting upper and lower motor neurons, with death resulting mainly from respiratory failure …
affecting upper and lower motor neurons, with death resulting mainly from respiratory failure …