Osteosarcoma (OS) is the most prevalent and fatal type of bone tumor. It is characterized by
great heterogeneity of genomic aberrations, mutated genes, and cell types contribution …

Melatonin, an endogenous neurohormone produced by the pineal gland, has received
increased interest due to its potential anti-cancer properties. Apart from its well-known role in …

Osteosarcoma stem cells (OSCs) contribute to the pathogenesis of osteosarcoma (OS),
which is the most common malignant primary bone tumor. The significance and underlying …

We developed cyclic RGD-tagged polymeric micellar nanoassemblies for sustained delivery
of Doxorubicin (Dox) endowed with significant cytotoxic effect against MG63, SAOS-2, and …

Osteosarcoma, which has poor prognosis after metastasis, is the most common type of bone
cancer in children and adolescents. Therefore, plant-derived bioactive compounds are …

Rationale: Osteosarcoma (OS), a common malignant bone tumor, calls for the investigation
of novel treatment strategies. Low-intensity vibration (LIV) presents itself as a promising …

The management of osteosarcoma (OS) patients presents a significant clinical challenge.
Despite progress in conventional and targeted therapies, the survival rate of OS patients …

Bone is the preferential site of metastasis for the most common tumors, including breast
cancer. On the other hand, osteosarcoma is the primary bone cancer that most commonly …

Osteosarcoma (OS) is a highly aggressive malignant tumor with a high rate of disability and
mortality rates, and dysregulated autophagy is a crucial factor in cancer. However, the …

Rationale: Osteosarcoma (OS) is the most common bone malignancy. c-MET is recognized
as a therapeutic target. However, traditional c-MET inhibitors show compromised efficacy …