[HTML][HTML] Bone tissue and histological and molecular events during development of the long bones

MJF Blumer - Annals of Anatomy-Anatomischer Anzeiger, 2021 - Elsevier
The bones are of mesenchymal or ectomesenchymal origin, form the skeleton of most
vertebrates, and are essential for locomotion and organ protection. As a living tissue they …

Urine excretion, organ distribution, and placental transfer of 6PPD and 6PPD-quinone in mice and potential developmental toxicity through nuclear receptor pathways

HN Zhao, SP Thomas, MJ Zylka… - Environmental …, 2023 - ACS Publications
The rubber antioxidant 6PPD has gained significant attention due to its highly toxic
transformation product, 6PPD-quinone (6PPDQ). Despite their detection in urines of …

Preparation of novel sea cucumber intestinal peptides to promote tibial fracture healing in mice by inducing differentiation of hypertrophic chondrocytes to the …

H Yin, H Yue, M Wang, T Zhang… - Molecular Nutrition & …, 2024 - Wiley Online Library
Scope Hypertrophic chondrocytes have a decisive regulatory role in the process of fracture
healing, and the fate of hypertrophic chondrocytes is not only apoptosis. However, the …

Child exposure to N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its derived quinone (6PPDQ) in e-waste areas: Urinary concentrations, sources …

Q Dai, Q Wang, J Zhang, Z Zhang, G Cao… - Journal of …, 2025 - Elsevier
Abstract N-(1, 3-dimethylbutyl)-N′-phenyl-p-phenylenediamine quinone (6PPDQ) and its
parent 6PPD are ubiquitous in the environment and may induce multi-endpoint toxicity …

Combined LXR and RXR agonist therapy increases ABCA1 protein expression and enhances ApoAI-mediated cholesterol efflux in cultured endothelial cells

K Huang, H Jo, J Echesabal-Chen, A Stamatikos - Metabolites, 2021 - mdpi.com
Endothelial ABCA1 expression protects against atherosclerosis and this atheroprotective
effect is partially attributed to enhancing apoAI-mediated cholesterol efflux. ABCA1 is a …

The retinoid X receptor α modulator K-80003 suppresses inflammatory and catabolic responses in a rat model of osteoarthritis

H Li, X Li, B Yang, J Su, S Cai, J Huang, T Hu… - Scientific Reports, 2021 - nature.com
Osteoarthritis (OA), a most common and highly prevalent joint disease, is closely associated
with dysregulated expression and modification of RXRα. However, the role of RXRα in the …

Selective β2-adrenoceptor blockade rescues mandibular growth retardation in adolescent rats exposed to chronic intermittent hypoxia

H Hong, J Hosomichi, H Maeda, Y Ishida… - Frontiers in …, 2021 - frontiersin.org
Activation of the sympathoadrenal system is associated with sleep apnea-related symptoms
and metabolic dysfunction induced by chronic intermittent hypoxia (IH). IH can induce …

Glycogen synthase kinase 3 alpha/beta deletion induces precocious growth plate remodeling in mice

SK Bali, D Bryce, C Prein, JR Woodgett… - Journal of Molecular …, 2021 - Springer
Glycogen synthase kinase (GSK) 3 acts to negatively regulate multiple signaling pathways,
including canonical Wnt signaling. The two mammalian GSK3 proteins (alpha and beta) are …

Glycogen synthase kinase 3 alpha/beta deletion induces precocious growth plate remodeling and cell loss in mice

SK Bali, D Bryce, C Prein, JR Woodgett, F Beier - bioRxiv, 2020 - biorxiv.org
Glycogen synthase kinase (GSK) 3 acts to negatively regulate multiple signaling pathways,
including canonical Wnt signaling. The two mammalian GSK3 proteins (alpha and beta) are …

Overexpression of Mig-6 in Limb Mesenchyme Leads to Accelerated Osteoarthritis in Mice

MR Bellini, MA Pest, JW Jeong, F Beier - bioRxiv, 2019 - biorxiv.org
ABSTRACT Background Mitogen-inducible gene 6 (Mig-6) is a tumour suppressor gene that
is also associated with the development of osteoarthritis (OA)-like disorder. Recent evidence …