Molecular docking is a theoretical simulation method based on bioinformatics, which studies
the interaction between molecules (such as ligands and receptors), and predicts their …

No drug has been approved to prevent neuronal cell loss in patients suffering from
Parkinson's disease (PD) or Alzheimer's disease (AD); despite increased comprehension of …

The inhibitory action of fifteen benzyloxy ortho/para-substituted chalcones (B1-B15) was
evaluated against human monoamine oxidases (hMAOs). All the molecules inhibited hMAO …

The enormous burden of the COVID-19 pandemic in economic and healthcare terms has
cast a shadow on the serious threat of antimicrobial resistance, increasing the inappropriate …

In the last years the continuous efforts in the development of novel and effective inhibitors of
human monoamine oxidases (hMAOs) promoted the discovery of new agents able to …

Thirteen isopropyl chalcones (CA1–CA13) were synthesized and evaluated for their
inhibitory activity against monoamine oxidase (MAO). All compounds inhibited MAO-B more …

Parkinson's disease is a neurodegenerative disorder characterized by slow movement,
tremors, and stiffness caused due to loss of dopaminergic neurons caused in the brain's …

Cholinesterase (ChE) and monoamine oxidase (MAO) inhibitors have been attracted as
candidate treatments for Alzheimer's disease (AD). Fifteen khellactone-type coumarins from …

Halogenated inhibitors showed robust, reversible, and selective monoamine oxidase-B
(MAO-B) inhibitory efficacy in candidates that were derived from them. Our team has …

The present study documents the synthesis of oxygenated chalcone (O1–O26) derivatives
and their abilities to inhibit monoamine oxidases. All 26 derivatives examined showed …