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Recent developments in molecular docking technology applied in food science: a review
X Tao, Y Huang, C Wang, F Chen… - … Journal of Food …, 2020 - academic.oup.com
Molecular docking is a theoretical simulation method based on bioinformatics, which studies
the interaction between molecules (such as ligands and receptors), and predicts their …
the interaction between molecules (such as ligands and receptors), and predicts their …
Emerging therapeutic potentials of dual‐acting MAO and AChE inhibitors in Alzheimer's and Parkinson's diseases
No drug has been approved to prevent neuronal cell loss in patients suffering from
Parkinson's disease (PD) or Alzheimer's disease (AD); despite increased comprehension of …
Parkinson's disease (PD) or Alzheimer's disease (AD); despite increased comprehension of …
Introduction of benzyloxy pharmacophore into aryl/heteroaryl chalcone motifs as a new class of monoamine oxidase B inhibitors
The inhibitory action of fifteen benzyloxy ortho/para-substituted chalcones (B1-B15) was
evaluated against human monoamine oxidases (hMAOs). All the molecules inhibited hMAO …
evaluated against human monoamine oxidases (hMAOs). All the molecules inhibited hMAO …
Biological investigation of N-methyl thiosemicarbazones as antimicrobial agents and bacterial carbonic anhydrases inhibitors
The enormous burden of the COVID-19 pandemic in economic and healthcare terms has
cast a shadow on the serious threat of antimicrobial resistance, increasing the inappropriate …
cast a shadow on the serious threat of antimicrobial resistance, increasing the inappropriate …
Chalcones: Unearthing their therapeutic possibility as monoamine oxidase B inhibitors
In the last years the continuous efforts in the development of novel and effective inhibitors of
human monoamine oxidases (hMAOs) promoted the discovery of new agents able to …
human monoamine oxidases (hMAOs) promoted the discovery of new agents able to …
Development of isopropyl-tailed chalcones as a new class of selective MAO-B inhibitors for the treatment of Parkinson's disorder
Thirteen isopropyl chalcones (CA1–CA13) were synthesized and evaluated for their
inhibitory activity against monoamine oxidase (MAO). All compounds inhibited MAO-B more …
inhibitory activity against monoamine oxidase (MAO). All compounds inhibited MAO-B more …
Recent updates on structural insights of MAO-B inhibitors: A review on target-based approach
Parkinson's disease is a neurodegenerative disorder characterized by slow movement,
tremors, and stiffness caused due to loss of dopaminergic neurons caused in the brain's …
tremors, and stiffness caused due to loss of dopaminergic neurons caused in the brain's …
Acetylcholinesterase and butyrylcholinesterase inhibitory activities of khellactone coumarin derivatives isolated from Peucedanum japonicum Thurnberg
JH Heo, BH Eom, HW Ryu, MG Kang, JE Park… - Scientific Reports, 2020 - nature.com
Cholinesterase (ChE) and monoamine oxidase (MAO) inhibitors have been attracted as
candidate treatments for Alzheimer's disease (AD). Fifteen khellactone-type coumarins from …
candidate treatments for Alzheimer's disease (AD). Fifteen khellactone-type coumarins from …
[HTML][HTML] A structural approach to investigate halogen substituted MAO-B inhibitors using QSAR modeling, molecular dynamics, and conceptual DFT analysis
Halogenated inhibitors showed robust, reversible, and selective monoamine oxidase-B
(MAO-B) inhibitory efficacy in candidates that were derived from them. Our team has …
(MAO-B) inhibitory efficacy in candidates that were derived from them. Our team has …
Design, synthesis and biological evaluation of oxygenated chalcones as potent and selective MAO-B inhibitors
The present study documents the synthesis of oxygenated chalcone (O1–O26) derivatives
and their abilities to inhibit monoamine oxidases. All 26 derivatives examined showed …
and their abilities to inhibit monoamine oxidases. All 26 derivatives examined showed …