Various explanations for the pathophysiology of migraines have been proposed; however,
none of these provide a complete explanation. The author critically reviews previous …

Globally, migraine is a leading cause of disability with a huge impact on both the work and
private life of affected persons. To overcome the societal migraine burden, better treatment …

Migraine is one of the most disabling and prevalent of all disorders. To improve
understanding of migraine mechanisms and to suggest a new therapeutic target, we …

Migraine, a primary headache disorder involving a dysfunctional trigeminal vascular system,
remains a major debilitating neurological condition impacting many patients' quality of life …

Background ATP‐sensitive potassium (KATP) channel opener levcromakalim induces
migraine attacks in migraine patients. Underlying mechanisms responsible for headache …

Migraine is a primary headache disorder ranked as the leading cause of years lived with
disability among individuals younger than 50 years. The aetiology of migraine is complex …

Background Opening of KATP channels by systemic levcromakalim treatment triggers
attacks in migraine patients and hypersensitivity to von Frey stimulation in a mouse model …

KIR6. 1 (KCNJ8) is a subunit of ATP sensitive potassium channel (KATP) that plays an
important role in the control of peripheral vascular tone and is highly expressed in brain …

Introduction Administration of ATP-sensitive potassium channel opener levcromakalim
triggers headache in healthy volunteers and migraine attacks in migraine patients. Here, we …

Glibenclamide inhibits sulfonylurea receptor (SUR), which regulates several ion channels
including SUR1-transient receptor potential melastatin 4 (SUR1-TRPM4) channel and ATP …