Having a hypoxic microenvironment is a common and salient feature of most solid tumors.
Hypoxia has a profound effect on the biological behavior and malignant phenotype of …

Cancer thermal therapy, also known as hyperthermia therapy, has long been exploited to
eradicate mass lesions that are now defined as cancer. With the development of …

Bacteria can bypass the blood-brain barrier (BBB), suggesting the possibility of employment
of bacteria for combating central nervous system diseases. Herein, we develop a bacteria …

As a promising cancer treatment, photodynamic therapy (PDT) still achieved limited clinical
success due to the severe hypoxia and programmed death ligand-1 (PD-L1) over-expressed …

Photodynamic therapy (PDT) continues to encounter multifarious hurdles, stemming from the
ineffectual preservation and delivery system of photosensitizers, the dearth of imaging …

Owing to the unique biological functions, bacteria as biological materials have been widely
used in biomedical field. With advances in biotechnology and nanotechnology, various …

Targeted therapy and immunotherapy have brought hopes for precision cancer treatment.
However, complex physiological barriers and tumor immunosuppression result in poor …

Immunotherapy continues to be in the spotlight of oncology therapy research in the past few
years and has been proven to be a promising option to modulate one's innate and adaptive …

Reactive oxygen species (ROS) can act as cytotoxic radicals to directly kill tumor cells and
concurrently trigger immunogenic cell death (ICD) to efficiently achieve tumor therapy. Thus …

Intratumoral environment as a hypoxic, non-inflamed “cold” state is difficult for many agents
to accumulate and activate the immune system. Intrinsically, facultative anaerobic …