Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours
Therapies with genetically modified T cells that express chimeric antigen receptors (CARs)
specific for CD19 or B cell maturation antigen (BCMA) are approved to treat certain B cell …
specific for CD19 or B cell maturation antigen (BCMA) are approved to treat certain B cell …
Single-cell atlases: shared and tissue-specific cell types across human organs
The development of single-cell and spatial transcriptomics methods was instrumental in the
conception of the Human Cell Atlas initiative, which aims to generate an integrated map of …
conception of the Human Cell Atlas initiative, which aims to generate an integrated map of …
Entry and exit of extracellular vesicles to and from the blood circulation
Extracellular vesicles (EVs) are biological nanoparticles that promote intercellular
communication by delivering bioactive cargo over short and long distances. Short-distance …
communication by delivering bioactive cargo over short and long distances. Short-distance …
Vascular endothelial cells: heterogeneity and targeting approaches
Forming the inner layer of the vascular system, endothelial cells (ECs) facilitate a multitude
of crucial physiological processes throughout the body. Vascular ECs enable the vessel wall …
of crucial physiological processes throughout the body. Vascular ECs enable the vessel wall …
[HTML][HTML] Allorecognition and the spectrum of kidney transplant rejection
J Callemeyn, B Lamarthée, A Koenig, P Koshy… - Kidney International, 2022 - Elsevier
Detection of mismatched human leukocyte antigens by adaptive immune cells is considered
as the main cause of transplant rejection, leading to either T-cell mediated rejection or …
as the main cause of transplant rejection, leading to either T-cell mediated rejection or …
A systems view of the vascular endothelium in health and disease
The dysfunction of blood-vessel-lining endothelial cells is a major cause of mortality.
Although endothelial cells, being present in all organs as a single-cell layer, are often …
Although endothelial cells, being present in all organs as a single-cell layer, are often …
Map** the human kidney using single-cell genomics
F Schreibing, R Kramann - Nature Reviews Nephrology, 2022 - nature.com
The field of single-cell genomics and spatial technologies is rapidly evolving and has
already provided unprecedented insights into complex tissues. Major advances have been …
already provided unprecedented insights into complex tissues. Major advances have been …
Vasculature organotropism in drug delivery
Over the past decades, there has been an exponential increase in the development of
preclinical and clinical nanodelivery systems, and recently, an accelerating demand to …
preclinical and clinical nanodelivery systems, and recently, an accelerating demand to …
Enhancing the safety of CAR-T cell therapy: Synthetic genetic switch for spatiotemporal control
L Lu, M **e, B Yang, W Zhao, J Cao - Science Advances, 2024 - science.org
Chimeric antigen receptor T (CAR-T) cell therapy is a promising and precise targeted
therapy for cancer that has demonstrated notable potential in clinical applications. However …
therapy for cancer that has demonstrated notable potential in clinical applications. However …
Adeno-associated virus–based gene therapy treats inflammatory kidney disease in mice
G Wu, S Liu, J Hagenstein, M Alawi, FE Hengel… - The Journal of clinical …, 2024 - jci.org
Adeno-associated virus (AAV) is a promising in vivo gene delivery platform showing
advantages in delivering therapeutic molecules to difficult or undruggable cells. However …
advantages in delivering therapeutic molecules to difficult or undruggable cells. However …