Recent advances in chemistry and therapeutic potential of functionalized quinoline motifs–a review

OO Ajani, KT Iyaye, OT Ademosun - RSC advances, 2022‏ - pubs.rsc.org
Quinoline, which consists of benzene fused with N-heterocyclic pyridine, has received
considerable attention as a core template in drug design because of its broad spectrum of …

Research developments in the syntheses, anti-inflammatory activities and structure–activity relationships of pyrimidines

H ur Rashid, MAU Martines, AP Duarte, J Jorge… - RSC …, 2021‏ - pubs.rsc.org
Pyrimidines are aromatic heterocyclic compounds that contain two nitrogen atoms at
positions 1 and 3 of the six-membered ring. Numerous natural and synthetic pyrimidines are …

Synthesis of diaminopyrimidine sulfonate derivatives and exploration of their structural and quantum chemical insights via SC-XRD and the DFT approach

A Ali, M Khalid, MN Tahir, M Imran, M Ashfaq… - ACS …, 2021‏ - ACS Publications
Two heterocyclic compounds named 2, 6-diaminopyrimidin-4-ylnaphthalene-2-sulfonate (A)
and 2, 6-diaminopyrimidin-4-yl4-methylbenzene sulfonate (B) were synthesized. The …

O-4-Acetylamino-benzenesulfonylated pyrimidine derivatives: synthesis, SC-XRD, DFT analysis and electronic behaviour investigation

M Khalid, A Ali, S Haq, MN Tahir, J Iqbal… - Journal of Molecular …, 2021‏ - Elsevier
Abstract Beginning with 2-amino-6-methyl-pyrimidin-4-ol and 2, 6-diamino-pyrimidin-4-ol, 2-
amino-6-methylpyrimidin-4-yl 4-acetamidobenzenesulfonate (APABS) and 2, 6 …

Efficient Synthesis, SC-XRD, and Theoretical Studies of O-Benzenesulfonylated Pyrimidines: Role of Noncovalent Interaction Influence in Their Supramolecular …

A Ali, M Khalid, MFU Rehman, S Haq, A Ali… - ACS …, 2020‏ - ACS Publications
Crystalline organic compounds, 2-amino-6-methylpyrimidin-4-yl benzenesulfonate (AMPBS)
and 2, 6-diaminopyrimidin-4-yl benzenesulfonate (DAPBS), were prepared via O …

Novel organic-inorganic nanohybrids (MnO2 and Ag nanoparticles functionalized 5-methoxy-2-mercaptobenzimidazole): one step synthesis and characterization

LA Adnan, NF Alheety, AH Majeed, MA Alheety… - Materials Today …, 2021‏ - Elsevier
The study included the synthesis of manganese dioxide nanoparticles using the nitric acid
by oxidation method. Moreover, the work involved the chemical synthesis of Ag metal …

[HTML][HTML] Medicinal attributes of pyrazolo [1, 5-a] pyrimidine based scaffold derivatives targeting kinases as anticancer agents

NSM Ismail, GME Ali, DA Ibrahim… - Future Journal of …, 2016‏ - Elsevier
Pyrazolo pyrimidines are fused heterocyclic ring systems which known as bioisosteres of
adenine, that are necessary for every aspect of cell life. Pyrazolo [1, 5-a] pyrimidines …

Synthesis, characterization, thermal, anticancer studies, and density functional theory for potentially active pyrimidine‐based complexes

FI Abouzayed, MS Mostafa… - Applied …, 2024‏ - Wiley Online Library
This work aimed to create and characterize some new bioactive chelates of bis azodye
ligand, 5‐((2‐hydroxy‐4, 6‐dioxo‐1, 4, 5, 6‐tetrahydropyrimidin‐5‐yl) diazenyl) naphthalen …

Recent advances in the synthesis of nitrogen-containing heterocyclic compounds via multicomponent reaction and their emerging biological applications: a review

Mallappa, M Chahar, N Choudhary, KK Yadav… - Journal of the Iranian …, 2024‏ - Springer
Nitrogen-containing heterocyclic compounds (NCHCs) have an important role in the field of
medicinal chemistry due to their extensive biological activities and their prevalence in …

Eco-friendly synthesis of pyrimidines and its derivatives: A review on broad spectrum bioactive moiety with huge therapeutic profile

F Jubeen, SZ Iqbal, N Shafiq, M Khan… - Synthetic …, 2018‏ - Taylor & Francis
Among all heterocyclic compounds, pyrimidine is of prime interest, exhibit broad spectrum of
biological activities, because of its occurrence in deoxyribonucleic acid bases. The bioactive …