Ischemia-reperfusion injury (IRI) constitutes a significant source of morbidity and mortality
after orthotopic liver transplantation (OLT). The allograft is metabolically impaired during …

Liver transplantation is the only recognized effective treatment for end-stage liver disease.
However, organ shortages have become the main challenge for patients and physicians …

Partial liver grafts from ex situ splitting are considered marginal due to prolonged static cold
storage. The use of ex situ hypothermic oxygenated perfusion (HOPE) may offer a strategy to …

Objective: The aim of this study was to maintain long-term full function and viability of partial
livers perfused ex situ for sufficient duration to enable ex situ treatment, repair, and …

Split-liver grafts are more vulnerable to ischemia/reperfusion injury (IRI) and primary
nonfunction (PNF) because of prolonged cold ischemia time (CIT) and surgical …

Liver transplantation is the only life-saving procedure for children with end-stage liver
disease. The field is however heterogenic with various graft types, recipient age, weight, and …

Normothermic machine perfusion has emerged as a method of assessing livers before
implantation and permits livers to be split ex vivo while perfused under normothermic …

Background Split liver transplantation addresses donor shortages by facilitating the
transplant of two recipients using one donor liver. Some still consider these grafts inferior …

Background: A major limitation in expanding the use of donation after circulatory death
(DCD) livers in transplantation is the increased risk of graft failure secondary to ischemic …

Recent advances in machine perfusion have revolutionised the field of transplantation by
prolonging preservation, permitting evaluation of viability prior to implant and rescue of …