Receptor modulators associated with the hypothalamus-pituitary-thyroid axis

X Cheng, H Zhang, S Guan, Q Zhao… - Frontiers in …, 2023 - frontiersin.org
The hypothalamus-pituitary-thyroid (HPT) axis maintains normal metabolic balance and
homeostasis in the human body through positive and negative feedback regulation. Its main …

Syringic acid protects against thioacetamide-induced hepatic encephalopathy: behavioral, biochemical, and molecular evidence

IF Okkay, U Okkay, OL Gundogdu, C Bayram… - Neuroscience …, 2022 - Elsevier
The objective of this study was to elucidate the effects of syringic acid on thioacetamide-
induced hepatic encephalopathy which is a complex serious syndrome with …

Phytochemical profiling of polyphenols and thyroid stimulatory activity of Ficus religiosa leaf extract in 6-propyl-thiouracil-induced hypothyroid rats

A Kar, D Mahar, S Biswas, D Chakraborty… - Journal of …, 2023 - Elsevier
Abstract Ethnopharmacological relevance The plant, Ficus religiosa (L.) from the family
Moraceae, has been extensively used in Ayurveda and Unani. Traditionally this plant is …

[HTML][HTML] Regulation of PTU-induced hypothyroidism in rats by caffeic acid primarily by activating thyrotropin receptors and by inhibiting oxidative stress

A Kar, S Panda, M Singh, S Biswas - Phytomedicine Plus, 2022 - Elsevier
Background Earlier, nothing was known on the thyroid-regulatory potential of caffeic acid
(CA). We investigated its role in 6-propyl-thiouracil (PTU)-induced hypothyroid rats and also …

Elucidating the role of phytocompounds from Brassica oleracea var. italic (Broccoli) on hyperthyroidism: an in-silico approach

DJP Daniel, S Shanmugasundaram… - In Silico …, 2024 - Springer
Thyroid hormone (TH) plays a crucial role in regulating the metabolism in every cell and all
organs in of the human body. TH also control the rate of calorie burning, body weight, and …

Quemeiteng granule relieves goiter by suppressing thyroid microvascular endothelial cell proliferation and angiogenesis via miR-217-5p-mediated targeting of FGF2 …

Y Li, W Yang, X Yang, A Ma, X Zhang, H Li… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Goiters are enlargements of the thyroid gland and are a
global public issue. Quemeiteng granule (QMTG) is a traditional Chinese medicine (TCM) …

A comparison between the anti-thyroid properties of methimazole and its derivatives with two S donor atoms endorsed by iodine adsorption capacity, docking and DFT …

M Bahrani-Pour, A Beheshti, T Sedaghat… - Journal of Molecular …, 2024 - Elsevier
Charge transfer adducts formed between iodine and several chemical families, such as
thiourea and its derivatives, thiocyanates, and isothiocyanates have been studied for their …

To elucidate the mechanism of “Scrophulariae Radix–Fritillaria” in goiter by integrated metabolomics and serum pharmaco-chemistry

L Chen, W Liang, K Zhang, Z Wang… - Frontiers in …, 2024 - frontiersin.org
The pharmacodynamic substances in “Scrophulariae Radix–Fritillaria” and the molecular
mechanisms underlying its therapeutic effects against goiter were analyzed through …

Haizao Yuhu decoctions including three species of glycyrrhiza protected against propylthiouracil-induced goiter with hypothyroidism in rats via the AMPK/mTOR …

N Li, M Li, L **u, W Liao, Y Ren, H Liu, S Chen… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Glycyrrhiza and sargassum are among the 18
incompatible medicaments according to traditional Chinese medicine (TCM) theory …

Phytochemicals: Promising Alternatives for Metabolic Regulation in Neurodegenerative Diseases

A Kar, S Panda - Altered Metabolism: A Major Contributor of …, 2024 - Springer
Neurodegenerative diseases (NDDs) are the disorders which involve the degeneration of
neurons, particularly present in the central nervous system (CNS). Despite the significant …