Opportunities and challenges of RiPP-based therapeutics

IPM Pfeiffer, MP Schröder, S Mordhorst - Natural Product Reports, 2024 - pubs.rsc.org
Covering: up to 2024 Ribosomally synthesised and post-translationally modified peptides
(RiPPs) comprise a substantial group of peptide natural products exhibiting noteworthy …

[HTML][HTML] Neuronal voltage-gated calcium channels: structure, function, and dysfunction

BA Simms, GW Zamponi - Neuron, 2014 - cell.com
Voltage-gated calcium channels are the primary mediators of depolarization-induced
calcium entry into neurons. There is great diversity of calcium channel subtypes due to …

Natural product and natural product derived drugs in clinical trials

MS Butler, AAB Robertson, MA Cooper - Natural product reports, 2014 - pubs.rsc.org
Covering: 2008–2013. Previous review: 2008, 25, 475 There are a significant number of
natural product (NP) drugs in development. We review the 100 NP and NP-derived …

[HTML][HTML] Peptide therapeutics from venom: Current status and potential

MW Pennington, A Czerwinski, RS Norton - Bioorganic & medicinal …, 2018 - Elsevier
Peptides are recognized as being highly selective, potent and relatively safe as potential
therapeutics. Peptides isolated from the venom of different animals satisfy most of these …

Marine peptides: Bioactivities and applications

RCF Cheung, TB Ng, JH Wong - Marine drugs, 2015 - mdpi.com
Peptides are important bioactive natural products which are present in many marine
species. These marine peptides have high potential nutraceutical and medicinal values …

An updated review on marine anticancer compounds: The use of virtual screening for the discovery of small-molecule cancer drugs

V Ruiz-Torres, JA Encinar, M Herranz-Lopez… - Molecules, 2017 - mdpi.com
Marine secondary metabolites are a promising source of unexploited drugs that have a wide
structural diversity and have shown a variety of biological activities. These compounds are …

[HTML][HTML] Neurotoxic alkaloids: saxitoxin and its analogs

M Wiese, PM D'Agostino, TK Mihali, MC Moffitt… - Marine drugs, 2010 - mdpi.com
Saxitoxin (STX) and its 57 analogs are a broad group of natural neurotoxic alkaloids,
commonly known as the paralytic shellfish toxins (PSTs). PSTs are the causative agents of …

Directed evolution of novel binding proteins

RC Ladner, SK Guterman, BL Roberts… - US Patent …, 1993 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
27399321&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Drug development from marine natural products

TF Molinski, DS Dalisay, SL Lievens… - Nature reviews Drug …, 2009 - nature.com
Drug discovery from marine natural products has enjoyed a renaissance in the past few
years. Ziconotide (Prialt; Elan Pharmaceuticals), a peptide originally discovered in a tropical …

Calcium-permeable ion channels in pain signaling

E Bourinet, C Altier, ME Hildebrand… - Physiological …, 2014 - journals.physiology.org
The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …