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Opportunities and challenges of RiPP-based therapeutics
IPM Pfeiffer, MP Schröder, S Mordhorst - Natural Product Reports, 2024 - pubs.rsc.org
Covering: up to 2024 Ribosomally synthesised and post-translationally modified peptides
(RiPPs) comprise a substantial group of peptide natural products exhibiting noteworthy …
(RiPPs) comprise a substantial group of peptide natural products exhibiting noteworthy …
[HTML][HTML] Neuronal voltage-gated calcium channels: structure, function, and dysfunction
BA Simms, GW Zamponi - Neuron, 2014 - cell.com
Voltage-gated calcium channels are the primary mediators of depolarization-induced
calcium entry into neurons. There is great diversity of calcium channel subtypes due to …
calcium entry into neurons. There is great diversity of calcium channel subtypes due to …
Natural product and natural product derived drugs in clinical trials
Covering: 2008–2013. Previous review: 2008, 25, 475 There are a significant number of
natural product (NP) drugs in development. We review the 100 NP and NP-derived …
natural product (NP) drugs in development. We review the 100 NP and NP-derived …
[HTML][HTML] Peptide therapeutics from venom: Current status and potential
Peptides are recognized as being highly selective, potent and relatively safe as potential
therapeutics. Peptides isolated from the venom of different animals satisfy most of these …
therapeutics. Peptides isolated from the venom of different animals satisfy most of these …
Marine peptides: Bioactivities and applications
RCF Cheung, TB Ng, JH Wong - Marine drugs, 2015 - mdpi.com
Peptides are important bioactive natural products which are present in many marine
species. These marine peptides have high potential nutraceutical and medicinal values …
species. These marine peptides have high potential nutraceutical and medicinal values …
An updated review on marine anticancer compounds: The use of virtual screening for the discovery of small-molecule cancer drugs
Marine secondary metabolites are a promising source of unexploited drugs that have a wide
structural diversity and have shown a variety of biological activities. These compounds are …
structural diversity and have shown a variety of biological activities. These compounds are …
[HTML][HTML] Neurotoxic alkaloids: saxitoxin and its analogs
Saxitoxin (STX) and its 57 analogs are a broad group of natural neurotoxic alkaloids,
commonly known as the paralytic shellfish toxins (PSTs). PSTs are the causative agents of …
commonly known as the paralytic shellfish toxins (PSTs). PSTs are the causative agents of …
Directed evolution of novel binding proteins
RC Ladner, SK Guterman, BL Roberts… - US Patent …, 1993 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
27399321&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
27399321&utm_source= google_patent&utm_medium= platform_link&utm_campaign …
Drug development from marine natural products
Drug discovery from marine natural products has enjoyed a renaissance in the past few
years. Ziconotide (Prialt; Elan Pharmaceuticals), a peptide originally discovered in a tropical …
years. Ziconotide (Prialt; Elan Pharmaceuticals), a peptide originally discovered in a tropical …
Calcium-permeable ion channels in pain signaling
The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …
dependent on a wide range of different types of voltage-and ligand-gated ion channels …