Histology permits the observation of otherwise invisible structures of the internal topography
of a specimen. Although it enables the investigation of tissues at a cellular level, it is invasive …

Alteration of brain aerobic glycolysis is often observed early in the course of Alzheimer's
disease (AD). Whether and how such metabolic dysregulation contributes to both synaptic …

Quantifying how the cellular composition of brain regions vary across development, aging,
sex, and disease, is crucial in experimental neuroscience, and the accuracy of different …

Volumetric brain atlases are increasingly used to integrate and analyze diverse
experimental neuroscience data acquired from animal models, but until recently a publicly …

Modern high throughput brain wide profiling techniques for cells and their morphology,
connectivity, and other properties, make the use of reference atlases with 3D coordinate …

It is now possible to record from hundreds of neurons across multiple brain regions in a
single electrophysiology experiment. An essential step in the ensuing data analysis is to …

Transgenic animal models are invaluable research tools for elucidating the pathways and
mechanisms involved in the development of neurodegenerative diseases. Mechanistic clues …

With recent technological advances in microscopy and image acquisition of tissue sections,
further developments of tools are required for viewing, transforming, and analyzing the ever …

Brain atlases are important reference resources for accurate anatomical description of
neuroscience data. Open access, three-dimensional atlases serve as spatial frameworks for …

Ex vivo imaging enables analysis of the human brain at a level of detail that is not possible
in vivo with MRI. In particular, histology can be used to study brain tissue at the microscopic …