Genome-wide association study for circulating metabolites in 619,372 individuals
Examining the downstream molecular consequences of genetic variation significantly
enhances our understanding of the heritable determinants of complex traits and disease …
enhances our understanding of the heritable determinants of complex traits and disease …
[HTML][HTML] Map** the genetic landscape of psychiatric disorders with the MiXeR toolset
Psychiatric disorders have complex genetic architectures with substantial genetic overlap
across conditions, which may partly explain their high levels of comorbidity. This presents …
across conditions, which may partly explain their high levels of comorbidity. This presents …
A genetic map of human metabolism across the allele frequency spectrum
Genetic studies of human metabolism identified unknown disease processes and novel
metabolic regulators, but have been limited in scale and allelic breadth. Here, we provide a …
metabolic regulators, but have been limited in scale and allelic breadth. Here, we provide a …
Divergent patterns of genetic overlap between severe mental disorders and metabolic markers
Background Bipolar disorder (BIP), major depressive disorder (MDD) and schizophrenia
(SCZ) are severe mental disorders (SMDs), each associated with poor cardiometabolic …
(SCZ) are severe mental disorders (SMDs), each associated with poor cardiometabolic …
Atlas of plasma metabolic markers linked to human brain morphology
Background Metabolic processes form the basis of the development, functioning and
maintenance of the brain. Despite accumulating evidence of the vital role of metabolism in …
maintenance of the brain. Despite accumulating evidence of the vital role of metabolism in …