Despite considerable progress in genome-and proteome-based high-throughput screening
methods and in rational drug design, the increase in approved drugs in the past decade did …

Abstract Systems pharmacology is an emerging area of pharmacology which utilizes
network analysis of drug action as one of its approaches. By considering drug actions and …

To target complex, multi-factorial diseases more effectively, there has been an emerging
trend of multi-target drug development based on network biology, as well as an increasing …

Alternative techniques and tools for analyzing biomolecular networks With the recent rapid
advances in molecular biology, high-throughput experimental methods have resulted in …

The Boolean network (BN) is a mathematical model of genetic networks and is based on
Boolean functions. Boolean functions are functions on the Boolean domain that consists of …

Background Drugs can influence the whole metabolic system by targeting enzymes which
catalyze metabolic reactions. The existence of interactions between drugs and metabolic …

The cellular network and its environment govern cell and organism behavior and are
fundamental to the comprehension of function, misfunction and drug discovery. Over the last …

Biomolecules do not perform their functions alone, but interactively with one another to form
so called biomolecular networks. It is well known that a complex disease stems from the …

It is of great theoretical interest and practical significance to study how to control a system by
applying perturbations to only a few driver nodes. Recently, a hot topic of modern network …

Background Efficient identification of drug targets is one of major challenges for drug
discovery and drug development. Traditional approaches to drug target identification include …