Brain activity during sleep is characterized by circuit-specific oscillations, including slow
waves, spindles and theta waves, which are nested in thalamocortical or hippocampal …

Sleep is evolutionarily conserved across all species, and impaired sleep is a common trait of
the diseased brain. Sleep quality decreases as we age, and disruption of the regular sleep …

The glymphatic system is responsible for brain-wide delivery of nutrients and clearance of
waste via influx of cerebrospinal fluid (CSF) alongside perivascular spaces and through the …

The characteristics of the sleep drivers and the mechanisms through which sleep relieves
the cellular homeostatic pressure are unclear. In flies, zebrafish, mice, and humans, DNA …

Abstract Slow waves (0.5–4 Hz) predominate in the cortical electroencephalogram during
non-rapid eye movement (NREM) sleep in mammals. They reflect the synchronization of …

Sleep is vital and universal across all species studied, and lack of sleep has detrimental
consequences for the organism. A broadly accepted theory for the purpose of sleep has yet …

Sleep is homeostatically regulated with sleep pressure accumulating with the increasing
duration of prior wakefulness. Yet, a clear understanding of the molecular components of the …

Mood disorders are often characterised by alterations in circadian rhythms, sleep
disturbances and seasonal exacerbation. Conversely, chronobiological treatments utilise …

The mechanisms by which sleep benefits learning and memory remain unclear. Sleep may
further strengthen the synapses potentiated by learning or promote broad synaptic …

Highlights•During slow-wave sleep cortical activity is dominated by spindles and slow
waves.•During wake cortical network displays activated patterns.•Overall sleep slow wave …