Use of rodents as models of human diseases
TF Vandamme - Journal of Pharmacy and Bioallied Sciences, 2014 - journals.lww.com
Advances in molecular biology have significantly increased the understanding of the biology
of different diseases. However, these discoveries have not yet been fully translated into …
of different diseases. However, these discoveries have not yet been fully translated into …
Research Progress on the Structure and Function of G3BP
W Kang, Y Wang, W Yang, J Zhang, H Zheng… - Frontiers in …, 2021 - frontiersin.org
Ras-GTPase-activating protein (SH3 domain)-binding protein (G3BP) is an RNA binding
protein. G3BP is a key component of stress granules (SGs) and can interact with many host …
protein. G3BP is a key component of stress granules (SGs) and can interact with many host …
G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling
Ras GTPase-activating protein-binding proteins 1 and 2 (G3BP1 and G3BP2, respectively)
are widely recognized as core components of stress granules (SGs). We report that G3BPs …
are widely recognized as core components of stress granules (SGs). We report that G3BPs …
Stress granule components G3BP1 and G3BP2 play a proviral role early in Chikungunya virus replication
FEM Scholte, A Tas, IC Albulescu, E Žusinaite… - Journal of …, 2015 - Am Soc Microbiol
Stress granules (SGs) are protein-mRNA aggregates that are formed in response to
environmental stresses, resulting in translational inhibition. SGs are generally believed to …
environmental stresses, resulting in translational inhibition. SGs are generally believed to …
MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer
Background Cancer cells develop resistance to chemotherapeutic intervention by excessive
formation of stress granules (SGs), which are modulated by an oncogenic protein G3BP2 …
formation of stress granules (SGs), which are modulated by an oncogenic protein G3BP2 …
The TSC complex-mTORC1 axis: from lysosomes to stress granules and back
U Rehbein, MT Prentzell… - Frontiers in Cell and …, 2021 - frontiersin.org
The tuberous sclerosis protein complex (TSC complex) is a key integrator of metabolic
signals and cellular stress. In response to nutrient shortage and stresses, the TSC complex …
signals and cellular stress. In response to nutrient shortage and stresses, the TSC complex …
G3BP1 promotes tumor progression and metastasis through IL-6/G3BP1/STAT3 signaling axis in renal cell carcinomas
Y Wang, D Fu, Y Chen, J Su, Y Wang, X Li, W Zhai… - Cell death & …, 2018 - nature.com
The chronic inflammatory microenvironment within or surrounding the primary renal cell
carcinoma (RCC) site promotes oncogenic transformation as well as contributes to the …
carcinoma (RCC) site promotes oncogenic transformation as well as contributes to the …
MicroRNA-23b targets Ras GTPase-activating protein SH3 domain-binding protein 2 to alleviate fibrosis and albuminuria in diabetic nephropathy
B Zhao, H Li, J Liu, P Han, C Zhang, H Bai… - Journal of The …, 2016 - journals.lww.com
Diabetic nephropathy (DN) is a frequent and severe complication of diabetes that is
structurally characterized by glomerular basement membrane thickening, extracellular …
structurally characterized by glomerular basement membrane thickening, extracellular …
Loss of G3BP1 suppresses proliferation, migration, and invasion of esophageal cancer cells via Wnt/β‐catenin and PI3K/AKT signaling pathways
LN Zhang, L Zhao, XL Yan… - Journal of cellular …, 2019 - Wiley Online Library
Accumulating evidence suggests that Ras GTPase‐activating protein SH3 domain‐binding
protein 1 (G3BP1) is very crucial to regulate tumorigenesis and metastasis. Recently, many …
protein 1 (G3BP1) is very crucial to regulate tumorigenesis and metastasis. Recently, many …
The roles and mechanisms of G3BP1 in tumour promotion
CH Zhang, JX Wang, ML Cai, R Shao, H Liu… - Journal of drug …, 2019 - Taylor & Francis
Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) is a SH3 domain-
binding protein that is overexpressed in a variety of tumour tissues and cancers, such as …
binding protein that is overexpressed in a variety of tumour tissues and cancers, such as …