Despite centuries since the discovery and study of cancer, cancer is still a lethal and
intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much …

Erythrocytes or red blood cells (RBCs) represent a promising cell-mediated drug delivery
platform due to their inherent biocompatibility. Here, we developed an antigen delivery …

Malignant melanoma is a highly metastatic type of cancer, which arises frequently from
transformed pigment cells and melanocytes as a result of long-term UV radiation exposure …

Abstract β-catenin is a multifunctional protein that plays crucial roles in embryonic
development, physiological homeostasis, and a wide variety of human cancers. Previously …

The tumor stroma and its cellular components are known to play an important role in tumor
response to treatment. Here, we report a novel resistance mechanism in melanoma that is …

Solid tumors have complex biology and structure comprising cancer cells, stromal cells, and
the extracellular matrix. While most therapeutics target the cancer cells, recent data suggest …

Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease. The pathogenesis of
IPF is not completely understood. However, numerous genes are associated with the …

Simple Summary Melanoma cells reside in a complex stromal microenvironment, which is a
critical component of disease onset and progression. Mesenchymal or fibroblastic cell type …

Background WD repeat and SOCS box containing protein (WSB) molecules have important
roles in tumorigenesis. WSB1 is dysfunctional in many malignancies. However, the effects of …

The hallmark of epithelial-to-mesenchymal transition (EMT) is the switch from epithelial
cadherin (E-cadherin) to neural cadherin (N-cadherin), allowing melanoma cells to form a …