Immune thrombocytopenia (ITP) is a complex autoimmune disease characterized by low
platelet counts. The pathogenesis of ITP remains unclear although both antibody-mediated …

Immune thrombocytopenia (ITP) occurs in 2 to 4/100 000 adults and results in variable
bleeding symptoms and thrombocytopenia. In the last decade, changes in our …

Platelets are small anucleate blood cells generated from megakaryocytes in the bone
marrow and cleared in the reticuloendothelial system. At the site of vascular injury, platelet …

Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder mediated by
antiplatelet autoantibodies and antigen-specific T cells that either destroy platelets …

Immune thrombocytopenia (ITP) is a rare disorder and meets the criteria for an orphan
disease. Expertise in the management of these patients is not widely spread. The following …

Platelets are small cellular fragments with the primary physiological role of maintaining
hemostasis. In addition to this well-described classical function, it is becoming increasingly …

Platelets, small anucleate cells circulating in the blood, are critical mediators in haemostasis
and thrombosis. Interestingly, recent studies demonstrated that platelets contain both pro …

Circulating cell-free DNA (cfDNA) fragments are a biological analyte with extensive utility in
diagnostic medicine. Understanding the source of cfDNA and mechanisms of release is …

Our previous clinical study showed that low-dose decitabine exhibited sustained responses
in nearly half of patients with refractory immune thrombocytopenia (ITP). The long-term …

Management of children with newly diagnosed immune thrombocytopenia (ITP) consists of
careful observation or immunomodulatory treatment. Observational studies suggest a lower …