Prediction of post‐translational glycosylation and phosphorylation of proteins from the amino acid sequence
Post‐translational modifications (PTMs) occur on almost all proteins analyzed to date. The
function of a modified protein is often strongly affected by these modifications and therefore …
function of a modified protein is often strongly affected by these modifications and therefore …
Intrinsically disordered proteins and intrinsically disordered protein regions
CJ Oldfield, AK Dunker - Annual review of biochemistry, 2014 - annualreviews.org
Intrinsically disordered proteins (IDPs) and IDP regions fail to form a stable structure, yet
they exhibit biological activities. Their mobile flexibility and structural instability are encoded …
they exhibit biological activities. Their mobile flexibility and structural instability are encoded …
The eukaryotic linear motif resource: 2022 release
M Kumar, S Michael, J Alvarado-Valverde… - Nucleic acids …, 2022 - academic.oup.com
Almost twenty years after its initial release, the Eukaryotic Linear Motif (ELM) resource
remains an invaluable source of information for the study of motif-mediated protein-protein …
remains an invaluable source of information for the study of motif-mediated protein-protein …
ELM—the eukaryotic linear motif resource in 2020
M Kumar, M Gouw, S Michael… - Nucleic acids …, 2020 - academic.oup.com
Studies on the DNA-binding properties of transcription factors are important in searching for
the downstream genes regulated by these factors. In the present study, we report on the …
the downstream genes regulated by these factors. In the present study, we report on the …
Understanding protein non-folding
VN Uversky, AK Dunker - Biochimica et Biophysica Acta (BBA)-Proteins …, 2010 - Elsevier
This review describes the family of intrinsically disordered proteins, members of which fail to
form rigid 3-D structures under physiological conditions, either along their entire lengths or …
form rigid 3-D structures under physiological conditions, either along their entire lengths or …
[HTML][HTML] Prediction of prime editing insertion efficiencies using sequence features and DNA repair determinants
Most short sequences can be precisely written into a selected genomic target using prime
editing; however, it remains unclear what factors govern insertion. We design a library of …
editing; however, it remains unclear what factors govern insertion. We design a library of …
Introducing protein intrinsic disorder
Proteins are the major component of the living cell. They play crucial roles in the
maintenance of life, and their dysfunctions are known to cause different pathologies. One of …
maintenance of life, and their dysfunctions are known to cause different pathologies. One of …
Protein disorder prediction: implications for structural proteomics
A great challenge in the proteomics and structural genomics era is to predict protein
structure and function, including identification of those proteins that are partially or wholly …
structure and function, including identification of those proteins that are partially or wholly …
Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I
The ubiquitin ligase TRIM25 mediates Lysine 63-linked ubiquitination of the N-terminal
CARD domains of the viral RNA sensor RIG-I to facilitate type I interferon (IFN) production …
CARD domains of the viral RNA sensor RIG-I to facilitate type I interferon (IFN) production …
Function and structure of inherently disordered proteins
AK Dunker, I Silman, VN Uversky… - Current opinion in …, 2008 - Elsevier
The application of bioinformatics methodologies to proteins inherently lacking 3D structure
has brought increased attention to these macromolecules. Here topics concerning these …
has brought increased attention to these macromolecules. Here topics concerning these …