From the laboratory perspective, effective management of patients with chronic myeloid
leukemia (CML) requires accurate diagnosis, assessment of prognostic markers, sequential …

The mainstay of treatment for adult patients with gliomas, glioneuronal and neuronal tumors
consists of combinations of surgery, radiotherapy, and chemotherapy. For many systemic …

There is a continuing debate about the proportion of cancer patients that benefit from
precision oncology, attributable in part to conflicting views as to which molecular alterations …

With the introduction of large-scale molecular profiling methods and high-throughput
sequencing technologies, the genomic features of most lymphoid neoplasms have been …

In the 5th edition of the WHO CNS tumor classification (CNS5, 2021), multiple molecular
characteristics became essential diagnostic criteria for many additional CNS tumor types …

Lesional focal epilepsy (LFE) is a common and severe seizure disorder caused by
epileptogenic lesions, including malformations of cortical development (MCD) and low …

The last decade has seen rapid progress in the use of genomic tests, including gene panels,
whole‐exome sequencing, and whole‐genome sequencing, in research and clinical cancer …

Cholangiocarcinomas (CCA) are a heterogeneous group of tumors that are classified as
intrahepatic, perihilar, or distal according to the anatomic location within the biliary tract …

Molecular biology is currently a fast-advancing science. Sequencing techniques are getting
cheaper, but the interpretation of genetic variants requires expertise and computational …

Abstract CIViC (Clinical Interpretation of Variants in Cancer; civicdb. org) is a crowd-sourced,
public domain knowledgebase composed of literature-derived evidence characterizing the …