Changes in body composition and weight loss frequently occur when humans are exposed
to hypoxic environments. The mechanisms thought to be responsible for these changes are …

High-intensity interval training (HIIT) and low-oxygen exposure may inhibit the secretion of
appetite-stimulating hormones, suppress appetite, and inhibit dietary intake. Physiological …

Poor musculoskeletal state is commonly observed in numerous clinical populations such as
chronic obstructive pulmonary disease (COPD) and heart failure patients. It, however …

Recent acute studies have shown that high‐intensity resistance circuit‐based (HRC) training
in hypoxia increases metabolic stress. However, no intervention studies have yet proven …

Our understanding of skeletal muscle structural and functional alterations during unloading
has increased in recent decades, yet the molecular mechanisms underpinning these …

Key points Superposition of hypoxia on 21 day bed rest did not worsen the impairment of
skeletal muscle oxidative function induced by bed rest alone. A significant impairment of …

Environmental hypoxia and inactivity have both been shown to modulate appetite. To
elucidate the independent and combined effects of hypoxia and bed rest-induced inactivity …

We explored the assembly of intestinal microbiota in healthy male participants during the run-
in (5 day) and experimental phases [21-day normoxic bed rest (NBR), hypoxic bedrest …

Muscle atrophy is a deleterious consequence of physical inactivity and is associated with
increased morbidity and mortality. The aim of this study was to decipher the mechanisms …

We explored the metagenomic, metabolomic and trace metal makeup of intestinal
microbiota and environment in healthy male participants during the run-in (5 day) and the …