Increasing attention has been paid to the diseases of central nervous system (CNS). The
penetration efficiency of most CNS drugs into the brain parenchyma is rather limited due to …

Patients with glioblastoma (GBM) have a universally poor prognosis and are in urgent need
of effective treatment strategies. Recent advances in sequencing techniques unraveled the …

The blood-brain barrier (BBB) poses a unique challenge for drug delivery to the central
nervous system (CNS). The BBB consists of a continuous layer of specialized endothelial …

Introduction Convection-enhanced delivery (CED) is a method of targeted, local drug
delivery to the central nervous system (CNS) that bypasses the blood-brain barrier (BBB) …

The central nervous system (CNS) poses a unique challenge for drug delivery. The blood–
brain barrier significantly hinders the passage of systemically delivered therapeutics and the …

The receptor for epidermal growth factor (EGFR) is a prime target for cancer therapy across
a broad variety of tumor types. As it is a tyrosine kinase, small molecule tyrosine kinase …

Neurodegenerative diseases are characterized by extensive loss of function or death of
brain cells, hampering the life quality of patients. Brain-targeted drug delivery is challenging …

Glioblastoma is the most common malignant brain tumor, and it carries an extremely poor
prognosis. Attempts to develop targeted therapies have been hindered because the blood …

The magnetic nanoparticle has emerged as a potential multifunctional clinical tool that can
provide cancer cell detection by magnetic resonance imaging (MRI) contrast enhancement …

Modern glioma surgery has evolved from the principal belief that safe, maximal tumor
resection improves symptom management, quality of life, progression-free survival, and …