Metastatic dissemination occurs very early in the malignant progression of a cancer but the
clinical manifestation of metastases often takes years. In recent decades, 5-year survival of …

Skeletal metastases are frequent complications of many cancers, causing bone
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …

Distant metastasis is a primary cause of mortality and contributes to poor surgical outcomes
in cancer patients. Before the development of organ-specific metastasis, the formation of a …

In metastasis, cancer cells travel around the circulation to colonize distant sites. Due to the
rarity of these events, the immediate fates of metastasizing tumor cells (mTCs) are poorly …

The period between" successful" treatment of localized breast cancer and the onset of
distant metastasis can last many years, representing an unexploited window to eradicate …

Real-time image-based sorting of target cells in a precisely indexed manner is desirable for
sequencing or cultivating individual human or microbial cells directly from clinical or …

Multiple factors act in concert to define the fate of disseminated tumor cells (DTC) to enter
dormancy or develop overt metastases. Here, we review these factors in the context of three …

A major cause of cancer recurrence following chemotherapy is cancer dormancy escape.
Taxane-based chemotherapy is standard of care in breast cancer treatment aimed at killing …

BACKGROUND Metastases are the hallmark of lethal cancer, though underlying
mechanisms that drive metastatic spread to specific organs remain poorly understood …

TGFβ signaling and the DNA damage response (DDR) are two cellular toolboxes with a
strong impact on cancer biology. While TGFβ as a pleiotropic cytokine affects essentially all …