Necrosis is a hallmark of several widespread diseases or their direct complications. In the
past decade, we learned that necrosis can be a regulated process that is potentially …

Recent findings from our group, obtained on experimental in vivo and ex vivo models of
pancreatitis, reveal that this disease causes a profound dysfunction of key cellular …

Objective Acute pancreatitis is caused by toxins that induce acinar cell calcium overload,
zymogen activation, cytokine release and cell death, yet is without specific drug therapy …

Background & Aims The pathogenic mechanism of pancreatitis is poorly understood. Recent
evidence implicates defective autophagy in pancreatitis responses; however, the pathways …

BACKGROUND & AIMS: Opening of the mitochondrial permeability transition pore (MPTP)
causes loss of the mitochondrial membrane potential (ΔΨm) and, ultimately, adenosine …

Knowledge of the molecular mechanisms of acute pancreatitis is largely based on studies
using rodents. To assess similar mechanisms in humans, we performed ex vivo pancreatitis …

Significance: Acute pancreatitis is an inflammatory disease of exocrine pancreas that carries
considerable morbidity and mortality; its pathophysiology remains poorly understood. During …

The differentiation of human pluripotent stem cells into pancreatic cells involves cellular
proliferation and apoptosis during cell fate transitions. However, their implications for …

Endothelial cells (ECs) apoptosis induced by oxidized low-density lipoprotein (ox-LDL) is
thought to play a critical role in atherosclerosis. MicroRNAs (miRNAs) are a class of …

Acute pancreatitis (AP) is a leading cause of death and is commonly accompanied by
systemic manifestations that are generally associated with a poor prognosis. Many cytokines …