Cardiovascular tissue engineering (CVTE) aims to create living tissues, with the ability to
grow and remodel, as replacements for diseased blood vessels and heart valves. Despite …

Heart valves function in one of the most mechanically demanding environments in the body
to ensure unidirectional blood flow. The resident valve interstitial cells respond to this …

Ischemic mitral regurgitation (IMR) is a prevalent cardiac disease associated with substantial
morbidity and mortality. Contemporary surgical treatments continue to have limited long-term …

Abstract Each year, more than 40,000 people undergo mitral valve (MV) repair surgery
domestically to treat regurgitation caused by myocardial infarction (MI). Although continual …

Unidirectional blood flow in the left side of the heart is regulated by the mitral valve. To better
understand the mitral valve function, researchers have examined the structural and …

Calcific aortic valve disease (CAVD) is characterized by progressive stiffening of aortic valve
(AV) tissues, inducing stenosis and insufficiency. Bicuspid aortic valve (BAV) is a common …

Aortic valves (AVs) undergo unique stretch histories that include high rates and magnitudes.
While major differences in deformation patterns have been observed between normal and …

The clinical and bioengineering arenas are experiencing tremendous technological
progress. Imaging technologies yield images with continuously improved time-and space …

Genetically modified mouse models provide a versatile and efficient platform to extend our
understanding of the underlying disease processes and evaluate potential treatments for …

This study evaluates the efficacy of annuloplasty repair as a standalone procedure for
treating bileaflet mitral valve prolapse with mitral regurgitation (MR). Various flexible ring …