On the dependency of cellular protein levels on mRNA abundance
The question of how genomic information is expressed to determine phenotypes is of central
importance for basic and translational life science research and has been studied by …
importance for basic and translational life science research and has been studied by …
The ecological roles of bacterial chemotaxis
How bacterial chemotaxis is performed is much better understood than why. Traditionally,
chemotaxis has been understood as a foraging strategy by which bacteria enhance their …
chemotaxis has been understood as a foraging strategy by which bacteria enhance their …
[BOOK][B] An introduction to systems biology: design principles of biological circuits
U Alon - 2019 - api.taylorfrancis.com
Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …
engineering approach to systems biology. Alon provides nicely written appendices to …
[HTML][HTML] Quantifying absolute protein synthesis rates reveals principles underlying allocation of cellular resources
Quantitative views of cellular functions require precise measures of rates of biomolecule
production, especially proteins—the direct effectors of biological processes. Here, we …
production, especially proteins—the direct effectors of biological processes. Here, we …
Network motifs: theory and experimental approaches
U Alon - Nature Reviews Genetics, 2007 - nature.com
Transcription regulation networks control the expression of genes. The transcription
networks of well-studied microorganisms appear to be made up of a small set of recurring …
networks of well-studied microorganisms appear to be made up of a small set of recurring …
The emergence of adaptive laboratory evolution as an efficient tool for biological discovery and industrial biotechnology
Harnessing the process of natural selection to obtain and understand new microbial
phenotypes has become increasingly possible due to advances in culturing techniques …
phenotypes has become increasingly possible due to advances in culturing techniques …
Interdependence of cell growth and gene expression: origins and consequences
M Scott, CW Gunderson, EM Mateescu, Z Zhang… - Science, 2010 - science.org
In bacteria, the rate of cell proliferation and the level of gene expression are intimately
intertwined. Elucidating these relations is important both for understanding the physiological …
intertwined. Elucidating these relations is important both for understanding the physiological …
Enzyme promiscuity: a mechanistic and evolutionary perspective
OKDS Tawfik - Annual review of biochemistry, 2010 - annualreviews.org
Many, if not most, enzymes can promiscuously catalyze reactions, or act on substrates, other
than those for which they evolved. Here, we discuss the structural, mechanistic, and …
than those for which they evolved. Here, we discuss the structural, mechanistic, and …
Adaptive laboratory evolution–principles and applications for biotechnology
M Dragosits, D Mattanovich - Microbial cell factories, 2013 - Springer
Adaptive laboratory evolution is a frequent method in biological studies to gain insights into
the basic mechanisms of molecular evolution and adaptive changes that accumulate in …
the basic mechanisms of molecular evolution and adaptive changes that accumulate in …
Ecology and evolution of metabolic cross-feeding interactions in bacteria
Literature covered: early 2000s to late 2017 Bacteria frequently exchange metabolites with
other micro-and macro-organisms. In these often obligate cross-feeding interactions, primary …
other micro-and macro-organisms. In these often obligate cross-feeding interactions, primary …