Engineering RNA export for measurement and manipulation of living cells
A system for programmable export of RNA molecules from living cells would enable both
non-destructive monitoring of cell dynamics and engineering of cells capable of delivering …
non-destructive monitoring of cell dynamics and engineering of cells capable of delivering …
Virus-host interactomics: new insights and opportunities for antiviral drug discovery
B De Chassey, L Meyniel-Schicklin, J Vonderscher… - Genome medicine, 2014 - Springer
The current therapeutic arsenal against viral infections remains limited, with often poor
efficacy and incomplete coverage, and appears inadequate to face the emergence of drug …
efficacy and incomplete coverage, and appears inadequate to face the emergence of drug …
HIV Rev-isited
CTS Truman, A Järvelin, I Davis… - Open Biology, 2020 - royalsocietypublishing.org
The human immunodeficiency virus type 1 (HIV-1) proteome is expressed from alternatively
spliced and unspliced genomic RNAs. However, HIV-1 RNAs that are not fully spliced are …
spliced and unspliced genomic RNAs. However, HIV-1 RNAs that are not fully spliced are …
[HTML][HTML] Scaffolding viral protein NC nucleates phase separation of the HIV-1 biomolecular condensate
Membraneless biomolecular condensates (BMCs) contribute to the replication of a growing
number of viruses but remain to be functionally characterized. Previously, we demonstrated …
number of viruses but remain to be functionally characterized. Previously, we demonstrated …
Dissection of affinity captured LINE-1 macromolecular complexes
Long Interspersed Nuclear Element-1 (LINE-1, L1) is a mobile genetic element active in
human genomes. L1-encoded ORF1 and ORF2 proteins bind L1 RNAs, forming …
human genomes. L1-encoded ORF1 and ORF2 proteins bind L1 RNAs, forming …
Interactions of HIV-1 capsid with host factors and their implications for develo** novel therapeutics
S Zhuang, BE Torbett - Viruses, 2021 - mdpi.com
The Human Immunodeficiency Virus type 1 (HIV-1) virion contains a conical shell, termed
capsid, encasing the viral RNA genome. After cellular entry of the virion, the capsid is …
capsid, encasing the viral RNA genome. After cellular entry of the virion, the capsid is …
Role of host tRNAs and aminoacyl-tRNA synthetases in retroviral replication
The lifecycle of retroviruses and retrotransposons includes a reverse transcription step,
wherein dsDNA is synthesized from genomic RNA for subsequent insertion into the host …
wherein dsDNA is synthesized from genomic RNA for subsequent insertion into the host …
Elucidating the in vivo interactome of HIV-1 RNA by hybridization capture and mass spectrometry
HIV-1 replication requires myriad interactions between cellular proteins and the viral
unspliced RNA. These interactions are important in archetypal RNA processes such as …
unspliced RNA. These interactions are important in archetypal RNA processes such as …
Noncanonical functions and cellular dynamics of the mammalian signal recognition particle components
C Faoro, SF Ataide - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
The signal recognition particle (SRP) is a ribonucleoprotein complex fundamental for co-
translational delivery of proteins to their proper membrane localization and secretory …
translational delivery of proteins to their proper membrane localization and secretory …
HIV-1 gag forms ribonucleoprotein complexes with unspliced viral RNA at transcription sites
KM Tuffy, RJK Maldonado, J Chang, P Rosenfeld… - Viruses, 2020 - mdpi.com
The ability of the retroviral Gag protein of Rous sarcoma virus (RSV) to transiently traffic
through the nucleus is well-established and has been implicated in genomic RNA (gRNA) …
through the nucleus is well-established and has been implicated in genomic RNA (gRNA) …