The developmental and epileptic encephalopathies encompass a group of rare syndromes
characterised by severe drug-resistant epilepsy with onset in childhood and significant …

Antiepileptic drugs (AEDs) are effective against seizures, but their use is often limited by
adverse effects, among them psychiatric and behavioral ones including aggressive behavior …

The PER a M panel pooled analys I s of effec T iveness and tolerability (PERMIT) study was
a pooled analysis of data from 44 real-world studies from 17 countries, in which people with …

Purpose To investigate the efficacy and tolerability of perampanel (PER) when administered
as a first add-on therapy to patients with focal epilepsy or idiopathic generalized epilepsy …

This article reviews the profile of perampanel, a novel noncompetitive α‐amino‐3‐hydroxyl‐
5‐methyl‐4‐isoxazole‐propionate (AMPA) receptor antagonist, and its role as a potential …

Objective To pool observational data on the routine use of perampanel to obtain information
on real‐world outcomes and data in populations typically underrepresented in clinical trials …

Purpose Perampanel, a selective, noncompetitive alpha-amino-3-hydroxy-5-methyl-4-
isoxazolepropionic acid (AMPA) antagonist, has been approved as an effective and safe …

This retrospective study assessed long‐term effectiveness of add‐on perampanel (PER) in
patients with Lennox–Gastaut syndrome (LGS). Outcomes included time to PER failure and …

Epilepsy is common in children and adolescents where its prevalence is 3.2–5.5/1000.
About one-third of patients also have attention deficit hyperactivity/impulsivity disorder …

Epileptic seizures are refractory to treatment in approximately one‐third of patients despite
the recent introduction of many newer antiepileptic drugs (AED s). Development of novel …