The S6K protein family in health and disease
The S6K proteins are mTOR pathway effectors and accumulative evidence suggest that
mTOR/S6K signaling contributes to several pathological conditions, such as diabetes …
mTOR/S6K signaling contributes to several pathological conditions, such as diabetes …
The impact of oxidative stress and AKT pathway on cancer cell functions and its application to natural products
Oxidative stress and AKT serine-threonine kinase (AKT) are responsible for regulating
several cell functions of cancer cells. Several natural products modulate both oxidative …
several cell functions of cancer cells. Several natural products modulate both oxidative …
MicroRNA-193a-3p and-5p suppress the metastasis of human non-small-cell lung cancer by downregulating the ERBB4/PIK3R3/mTOR/S6K2 signaling pathway
The metastatic cascade is a complex and multistep process with many potential barriers.
Recent evidence has shown that microRNAs (miRNAs) are involved in carcinogenesis and …
Recent evidence has shown that microRNAs (miRNAs) are involved in carcinogenesis and …
[HTML][HTML] p53 and metabolism: from mechanism to therapeutics
The tumor cell changes itself and its microenvironment to adapt to different situations,
including action of drugs and other agents targeting tumor control. Therefore, metabolism …
including action of drugs and other agents targeting tumor control. Therefore, metabolism …
Distinct roles of mTOR targets S6K1 and S6K2 in breast cancer
S Sridharan, A Basu - International journal of molecular sciences, 2020 - mdpi.com
The mechanistic target of rapamycin (mTOR) is a master regulator of protein translation,
metabolism, cell growth and proliferation. It forms two complexes, mTOR complex 1 …
metabolism, cell growth and proliferation. It forms two complexes, mTOR complex 1 …
The HER2 signaling network in breast cancer—like a spider in its web
A Dittrich, H Gautrey, D Browell… - Journal of mammary gland …, 2014 - Springer
The human epidermal growth factor receptor 2 (HER2) is a major player in the survival and
proliferation of tumour cells and is overexpressed in up to 30% of breast cancer cases. A …
proliferation of tumour cells and is overexpressed in up to 30% of breast cancer cases. A …
Selective abrogation of S6K2 identifies lipid homeostasis as a survival vulnerability in MAPK inhibitor–resistant NRAS-mutant melanoma
B Lipchick, AN Guterres, HY Chen… - Science Translational …, 2025 - science.org
Although oncogenic NRAS activates mitogen-activated protein kinase (MAPK) signaling,
inhibition of the MAPK pathway is not therapeutically efficacious in NRAS-mutant (NRAS …
inhibition of the MAPK pathway is not therapeutically efficacious in NRAS-mutant (NRAS …
Cordycepin augments the chemosensitivity of osteosarcoma to cisplatin by activating AMPK and suppressing the AKT signaling pathway
HB Li, JK Chen, ZX Su, QL **, LW Deng… - Cancer Cell …, 2021 - Springer
Background Osteosarcoma is the most common primary bone tumor in children and
adolescents. However, some patients with osteosarcoma develop resistance to …
adolescents. However, some patients with osteosarcoma develop resistance to …
The epidemiology and molecular mechanisms linking obesity, diabetes, and cancer
RD Ferguson, EJ Gallagher, EJ Scheinman… - Vitamins & …, 2013 - Elsevier
The worldwide epidemic of obesity is associated with increasing rates of the metabolic
syndrome and type 2 diabetes. Epidemiological studies have reported that these conditions …
syndrome and type 2 diabetes. Epidemiological studies have reported that these conditions …
Mammalian EAK-7 activates alternative mTOR signaling to regulate cell proliferation and migration
Nematode EAK-7 (enhancer-of-akt-1-7) regulates dauer formation and controls life span;
however, the function of the human ortholog mammalian EAK-7 (mEAK-7) is unknown. We …
however, the function of the human ortholog mammalian EAK-7 (mEAK-7) is unknown. We …