Safety and immunogenicity of the therapeutic vaccine TG1050 in chronic hepatitis B patients: a phase 1b placebo-controlled trial
Treatment of chronic hepatitis B (CHB) typically requires life-long administration of drugs.
Cohort and pre-clinical studies have established the link between a functional T-cell …
Cohort and pre-clinical studies have established the link between a functional T-cell …
T cell receptor profiling in type 1 diabetes
Abstract Purpose of Review The genetic susceptibility and dominant protection for type 1
diabetes (T1D) associated with human leukocyte antigen (HLA) haplotypes, along with …
diabetes (T1D) associated with human leukocyte antigen (HLA) haplotypes, along with …
The mutation-associated neoantigen functional expansion of specific T cells (MANAFEST) assay: a sensitive platform for monitoring antitumor immunity
Mutation-associated neoantigens (MANA) are a target of antitumor T-cell immunity.
Sensitive, simple, and standardized assays are needed to assess the repertoire of functional …
Sensitive, simple, and standardized assays are needed to assess the repertoire of functional …
Age-related distribution and dynamics of T-cells in blood and lymphoid tissues of goats
Neonatal mammals have increased disease susceptibility and sub-optimal vaccine
responses. This raises problems in both humans and farm animals. The high prevalence of …
responses. This raises problems in both humans and farm animals. The high prevalence of …
DNA vaccination by electroporation amplifies broadly cross-restricted public TCR clonotypes shared with HIV controllers
M Mukhopadhyay, M Galperin… - The Journal of …, 2017 - journals.aai.org
Rare patients who spontaneously control HIV replication provide a useful model to inform
HIV vaccine development. HIV controllers develop particularly efficient antiviral CD4+ T cell …
HIV vaccine development. HIV controllers develop particularly efficient antiviral CD4+ T cell …
Transient IL-10 receptor blockade can enhance CD8+ T cell responses to a simian adenovirus-vectored HIV-1 conserved region immunogen
G Clutton, A Bridgeman… - Human vaccines & …, 2015 - Taylor & Francis
Viral vector vaccines designed to elicit CD8+ T cells in non-human primates exert potent
control of immunodeficiency virus infections; however, similar approaches have been …
control of immunodeficiency virus infections; however, similar approaches have been …
Vaccine targeting of subdominant CD8+ T cell epitopes increases the breadth of the T cell response upon viral challenge, but may impair immediate virus control
MA Steffensen, LH Pedersen, ML Jahn… - The Journal of …, 2016 - journals.aai.org
As a result of the difficulties in making efficient vaccines against genetically unstable viruses
such as HIV, it has been suggested that future vaccines should preferentially target …
such as HIV, it has been suggested that future vaccines should preferentially target …