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A simple yet multifaceted 90 years old, evergreen enzyme: Carbonic anhydrase, its inhibition and activation
Advances in the carbonic anhydrase (CA, EC 4.2. 1.1) research over the last three decades
are presented, with an emphasis on the deciphering of the activation mechanism, the …
are presented, with an emphasis on the deciphering of the activation mechanism, the …
Emerging role of carbonic anhydrase inhibitors
Inhibition of carbonic anhydrase (CA, EC 4.2. 1.1) was clinically exploited for decades, as
most modern diuretics were obtained considering as lead molecule acetazolamide, the …
most modern diuretics were obtained considering as lead molecule acetazolamide, the …
Carbonic anhydrase and bacterial metabolism: a chance for antibacterial drug discovery
ABSTRACT Introduction Carbonic anhydrases (CAs, EC 4.2. 1.1) play a pivotal role in the
regulation of carbon dioxide, bicarbonate, and hydrogen ions within bacterial cells, ensuring …
regulation of carbon dioxide, bicarbonate, and hydrogen ions within bacterial cells, ensuring …
An overview of novel antimicrobial carbonic anhydrase inhibitors
Introduction Four different genetic families of the enzyme carbonic anhydrase (CA, EC 4.2.
1.1) are present in bacteria, α-, β-, γ-and ι-CAs. They play relevant functions related to CO2 …
1.1) are present in bacteria, α-, β-, γ-and ι-CAs. They play relevant functions related to CO2 …
Exploring the multiple binding modes of inhibitors to carbonic anhydrases for novel drug discovery
Introduction The spacious active site cavity of the metalloenzyme carbonic anhydrase (CA,
EC 4.2. 1.1) shows a great versatility for a variety of binding modes for modulators of activity …
EC 4.2. 1.1) shows a great versatility for a variety of binding modes for modulators of activity …
Selected strategies to fight pathogenic bacteria
Natural products and analogues are a source of antibacterial drug discovery. Considering
drug resistance levels emerging for antibiotics, identification of bacterial metalloenzymes …
drug resistance levels emerging for antibiotics, identification of bacterial metalloenzymes …
Antibacterial carbonic anhydrase inhibitors: an update on the recent literature
Introduction The clinically licensed drugs used as antibiotics prevent the microbial growth
interfering with the biosynthesis of proteins, nucleic acids, microorganism wall biosynthesis …
interfering with the biosynthesis of proteins, nucleic acids, microorganism wall biosynthesis …
Multi-and poly-pharmacology of carbonic anhydrase inhibitors
Eight genetically distinct families of the enzyme carbonic anhydrase (CA, EC 4.2. 1.1) were
described in organisms allover the phylogenetic tree. They catalyze the hydration of CO 2 to …
described in organisms allover the phylogenetic tree. They catalyze the hydration of CO 2 to …
Bacterial ι-carbonic anhydrase: a new active class of carbonic anhydrase identified in the genome of the Gram-negative bacterium Burkholderia territorii
The carbonic anhydrases (CAs, EC 4.2. 1.1) catalyse a simple but physiologically crucial
reversible reaction, the carbon dioxide hydration with the production of bicarbonate and …
reversible reaction, the carbon dioxide hydration with the production of bicarbonate and …
Multiple Binding Modes of Inhibitors to Human Carbonic Anhydrases: An Update on the Design of Isoform-Specific Modulators of Activity
K D'Ambrosio, A Di Fiore, V Alterio, E Langella… - Chemical …, 2024 - ACS Publications
Human carbonic anhydrases (hCAs) are widespread zinc enzymes that catalyze the
hydration of CO2 to bicarbonate and a proton. Currently, 15 isoforms have been identified, of …
hydration of CO2 to bicarbonate and a proton. Currently, 15 isoforms have been identified, of …