Atopic dermatitis endotypes and implications for targeted therapeutics

T Czarnowicki, H He, JG Krueger… - Journal of Allergy and …, 2019 - Elsevier
Recent research advancements indicate that atopic dermatitis (AD) is a complex disease
characterized by different subtypes/phenotypes based on age, disease chronicity, ethnicity …

Update on atopic dermatitis

T Torres, EO Ferreira, M Gonçalo… - Acta medica …, 2019 - baes.uc.pt
With an increasing prevalence during the past decades, atopic dermatitis has become a
global health issue. A literature search following a targeted approach was undertaken to …

Baricitinib in patients with moderate‐to‐severe atopic dermatitis and inadequate response to topical corticosteroids: results from two randomized monotherapy phase …

EL Simpson, JP Lacour, L Spelman… - British Journal of …, 2020 - academic.oup.com
Background Baricitinib, an oral selective Janus kinase 1 and 2 inhibitor, effectively reduced
atopic dermatitis (AD) severity in a phase II study with concomitant topical corticosteroids …

[HTML][HTML] Dupilumab progressively improves systemic and cutaneous abnormalities in patients with atopic dermatitis

E Guttman-Yassky, R Bissonnette, B Ungar… - Journal of Allergy and …, 2019 - Elsevier
Background Dupilumab is an IL-4 receptor α mAb inhibiting signaling of IL-4 and IL-13, key
drivers of type 2–driven inflammation, as demonstrated by its efficacy in patients with …

Epidemiology of atopic dermatitis in adults: results from an international survey

S Barbarot, S Auziere, A Gadkari, G Girolomoni… - Allergy, 2018 - Wiley Online Library
Background There are gaps in our knowledge of the prevalence of adult atopic dermatitis
(AD). Objective To estimate the prevalence of AD in adults and by disease severity. Methods …

[HTML][HTML] Patient burden and quality of life in atopic dermatitis in US adults: a population-based cross-sectional study

JI Silverberg, JM Gelfand, DJ Margolis… - Annals of Allergy …, 2018 - Elsevier
Background The patient burden and quality of life (QOL) impact of atopic dermatitis (AD) in
the United States population is not well established. Objective To elucidate the patient …

Disease modification in inflammatory skin disorders: opportunities and challenges

T Bieber - Nature Reviews Drug Discovery, 2023 - nature.com
Progress in understanding of the mechanisms underlying chronic inflammatory skin
disorders, such as atopic dermatitis and psoriasis vulgaris, has led to new treatment options …

Unmet medical needs in chronic, non-communicable inflammatory skin diseases

H Ujiie, D Rosmarin, MP Schön, S Ständer… - Frontiers in …, 2022 - frontiersin.org
An estimated 20–25% of the population is affected by chronic, non-communicable
inflammatory skin diseases. Chronic skin inflammation has many causes. Among the most …

The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies

PM Brunner, E Guttman-Yassky, DYM Leung - Journal of Allergy and …, 2017 - Elsevier
Atopic dermatitis (AD), the most common chronic inflammatory skin disease, is driven by
both terminal keratinocyte differentiation defects and strong type 2 immune responses. In …

Efficacy and safety of dupilumab in adolescents with uncontrolled moderate to severe atopic dermatitis: a phase 3 randomized clinical trial

EL Simpson, AS Paller, EC Siegfried… - JAMA …, 2020 - jamanetwork.com
Importance Adolescents with atopic dermatitis (AD) have high disease burden negatively
affecting quality of life, with limited treatment options. The efficacy and safety of dupilumab, a …