In contrast to nitric oxide, which has well established and important roles in the regulation of
blood flow and thrombosis, neurotransmission, the normal functioning of the genitourinary …

Arterial stiffness progressively increases with aging and is an independent predictor of
cardiovascular disease (CVD) risk. Evidence supports that there are sex differences in the …

Nicotinamide adenine dinucleotide (NAD+) has emerged as a critical co-substrate for
enzymes involved in the beneficial effects of regular calorie restriction on healthspan. As …

Excess reactive oxygen species production by mitochondria is a key mechanism of age-
related vascular dysfunction. Our laboratory has shown that supplementation with the …

Age-related vascular endothelial dysfunction is a major antecedent to cardiovascular
diseases. We investigated whether increased circulating levels of the gut microbiome …

Chronic calorie restriction (CR) improves cardiovascular function and several other
physiological markers of healthspan. However, CR is impractical in non-obese older …

We hypothesized that curcumin would improve resistance and conduit artery endothelial
function and large elastic artery stiffness in healthy middle-aged and older adults. Thirty-nine …

Nitric oxide (NO) is a gaseous signaling molecule that plays an important role in myriad
physiological processes including the regulation of vascular tone, neurotransmission …

Cardiovascular disease (CVD) affects one in three adults and remains the leading cause of
death in America. Advancing age is a major risk factor for CVD. Recent plateaus in CVD …

Aging is associated with stiffening of the large elastic arteries and consequent increases in
systolic blood pressure (SBP), which together increase cardiovascular disease risk; …