A guide to single-particle tracking

F Simon, LE Weiss, S van Teeffelen - Nature Reviews Methods Primers, 2024 - nature.com
Individual proteins and protein complexes undergo various motion types, including free
diffusion, confinement, subdiffusion and directed motion. Different motion behaviours reflect …

Manipulation and motion of organelles and single molecules in living cells

K Norregaard, R Metzler, CM Ritter… - Chemical …, 2017 - ACS Publications
The biomolecule is among the most important building blocks of biological systems, and a
full understanding of its function forms the scaffold for describing the mechanisms of higher …

Anomalous diffusion models and their properties: non-stationarity, non-ergodicity, and ageing at the centenary of single particle tracking

R Metzler, JH Jeon, AG Cherstvy… - Physical Chemistry …, 2014 - pubs.rsc.org
Modern microscopic techniques following the stochastic motion of labelled tracer particles
have uncovered significant deviations from the laws of Brownian motion in a variety of …

A toolbox for determining subdiffusive mechanisms

Y Meroz, IM Sokolov - Physics Reports, 2015 - Elsevier
Subdiffusive processes have become a field of great interest in the last decades, due to
amounting experimental evidence of subdiffusive behavior in complex systems, and …

Stochastic resetting: A (very) brief review

S Gupta, AM Jayannavar - Frontiers in Physics, 2022 - frontiersin.org
Stochastic processes offer a fundamentally different paradigm of dynamics than
deterministic processes that one is most familiar with, the most prominent example of the …

Superdiffusion dominates intracellular particle motion in the supercrowded cytoplasm of pathogenic Acanthamoeba castellanii

JF Reverey, JH Jeon, H Bao, M Leippe, R Metzler… - Scientific reports, 2015 - nature.com
Acanthamoebae are free-living protists and human pathogens, whose cellular functions and
pathogenicity strongly depend on the transport of intracellular vesicles and granules through …

From a melt of rings to chromosome territories: the role of topological constraints in genome folding

JD Halverson, J Smrek, K Kremer… - Reports on Progress in …, 2014 - iopscience.iop.org
We review pro and contra of the hypothesis that generic polymer properties of topological
constraints are behind many aspects of chromatin folding in eukaryotic cells. For that …

Loss of lamin A function increases chromatin dynamics in the nuclear interior

I Bronshtein, E Kepten, I Kanter, S Berezin… - Nature …, 2015 - nature.com
Chromatin is organized in a highly ordered yet dynamic manner in the cell nucleus, but the
principles governing this organization remain unclear. Similarly, it is unknown whether, and …

Cytoplasmic RNA-protein particles exhibit non-Gaussian subdiffusive behavior

TJ Lampo, S Stylianidou, MP Backlund, PA Wiggins… - Biophysical journal, 2017 - cell.com
The cellular cytoplasm is a complex, heterogeneous environment (both spatially and
temporally) that exhibits viscoelastic behavior. To further develop our quantitative insight into …

Anomalous diffusion, aging, and nonergodicity of scaled Brownian motion with fractional Gaussian noise: Overview of related experimental observations and models

W Wang, R Metzler, AG Cherstvy - Physical Chemistry Chemical …, 2022 - pubs.rsc.org
How does a systematic time-dependence of the diffusion coefficient D (t) affect the ergodic
and statistical characteristics of fractional Brownian motion (FBM)? Here, we answer this …