Gametogenesis in animal oocytes reduces the diploid genome content of germline
precursors to a haploid state in gametes by discarding ¾ of the duplicated chromosomes …

Organisms that reproduce sexually utilize a specialized form of cell division called meiosis to
reduce their chromosome number by half to generate haploid gametes. Meiosis in females …

In contrast to somatic cells, formation of acentriolar meiotic spindles relies on the
organization of microtubules (MTs) and MT-organizing centers (MTOCs) into a stable bipolar …

The mitotic spindle is defined by its organized, bipolar mass of microtubules, which drive
chromosome alignment and segregation. Although different cells have been shown to use …

In sexually reproducing animals, oocytes arrest at diplotene or diakinesis and resume
meiosis (meiotic maturation) in response to hormones. Chromosome segregation errors in …

Anaphase is tightly controlled spatiotemporally to ensure proper separation of
chromosomes. 1, 2, 3 The mitotic spindle, the self-organized microtubule structure driving …

The Caenorhabditis elegans one-cell embryo is a powerful system in which to study
microtubule organization because this large cell assembles both meiotic and mitotic …

During cell division, a bipolar array of microtubules forms the spindle through which the
forces required for chromosome segregation are transmitted. Interestingly, the spindle as a …

The accurate segregation of duplicated chromosomes, essential for the development and
viability of a eukaryotic organism, requires the formation of a robust microtubule (MT)-based …

Generation of a haploid female germ cell, the egg, consists of two rounds of asymmetric cell
division (meiosis I and meiosis II), yielding two diminutive and nonviable polar bodies and a …