Isatins as privileged molecules in design and synthesis of spiro-fused cyclic frameworks

GS Singh, ZY Desta - Chemical Reviews, 2012 - ACS Publications
1. INTRODUCTION Indoline-2, 3-dione or indole-1H-2, 3-dione (Figure 1), commonly known
as isatin, is a well-known natural product found in plants of genus Isatis and in Couropita …

Recent advances in diversity oriented synthesis through isatin‐based multicomponent reactions

Y Liu, H Wang, J Wan - Asian Journal of Organic Chemistry, 2013 - Wiley Online Library
Isatins are well‐known carbonyl electrophiles which allow a vast number of reactions
initiated by nucleophilic attack on the C3 carbonyl group when used as starting materials …

Synthesis of 2,3-Dihydroquinazolin-4(1H)-ones by Three-Component Coupling of Isatoic Anhydride, Amines, and Aldehydes Catalyzed by Magnetic Fe3O4 …

ZH Zhang, HY Lu, SH Yang… - Journal of combinatorial …, 2010 - ACS Publications
A simple and efficient protocol for one-pot three-component coupling of isatoic anhydride,
amines, and aldehydes in water using magnetically recoverable Fe3O4 nanoparticles is …

Recent advances in the chemistry of imine-based multicomponent reactions (MCRs)

LH Choudhury, T Parvin - Tetrahedron, 2011 - Elsevier
Nitrogen-containing compounds are ubiquitous in nature and many of them are biologically
active (eg, 1, 2, 3, 4; Fig. 1). The nitrogen-containing units of these molecules play important …

Recent progress on routes to spirooxindole systems derived from isatin

M **a, RZ Ma - Journal of Heterocyclic Chemistry, 2014 - Wiley Online Library
Because of their definite or potential biological and pharmaceutical activities, spirooxindole
heterocycles have been widely studied, and there has occurred a research boom on routes …

Facile Method for the Combinatorial Synthesis of 2,2-Disubstituted Quinazolin-4(1H)-one Derivatives Catalyzed by Iodine in Ionic Liquids

XS Wang, K Yang, J Zhou, SJ Tu - Journal of Combinatorial …, 2010 - ACS Publications
A mild and facile method for the combinatorial synthesis of quinazolin-4-(1 H)-one
derivatives, containing simple 2, 2-disubstituted quinazolin-4-(1 H)-ones, spirocyclic …

[HTML][HTML] Ultrasound-assisted one-pot, three-component synthesis of spiro [indoline-3, 4′-pyrazolo [3, 4-b] pyridine]-2, 6′(1′ H)-diones in water

A Bazgir, S Ahadi, R Ghahremanzadeh… - Ultrasonics …, 2010 - Elsevier
A simple, facile, efficient and three-component procedure for the synthesis of spiro [indoline-
3, 4′-pyrazolo [3, 4-b] pyridine]-2, 6′(1′ H)-diones by the reaction of 4-hydroxycumarin …

Utilization of isatoic anhydride in the syntheses of various types of quinazoline and quinazolinone derivatives

SY Abbas, KAM El-Bayouki… - Synthetic …, 2016 - Taylor & Francis
Isatoic anhydride has attracted a great deal of attention in recent decades. A review of the
methods of preparation of all known quinazoline and quinazolinone derivatives is given …

Ethylenediamine diacetate-catalyzed three-component reaction for the synthesis of 2, 3-dihydroquinazolin-4 (1H)-ones and their spirooxindole derivatives

M Narasimhulu, YR Lee - Tetrahedron, 2011 - Elsevier
Ethylenediamine diacetate (EDDA)-catalyzed one-pot syntheses of biologically interesting 2,
3-dihydroquinazolin-4 (1H)-ones and their spirooxindole derivatives from isatoic anhydride …

Ultrasound-based approach to spiro-2, 3-dihydroquinazolin-4 (1H)-ones: their in vitro evaluation against chorismate mutase

D Rambabu, SK Kumar, BY Sreenivas, S Sandra… - Tetrahedron …, 2013 - Elsevier
Amberlyst-15 has been identified as a green and reusable catalyst in the synthesis of spiro
2, 3-dihydroquinazolin-4 (1H)-ones under ultrasound irradiation at room temperature. The …