The gut microbiome: Relationships with disease and opportunities for therapy

J Durack, SV Lynch - Journal of experimental medicine, 2019 - rupress.org
Over the past decade, our view of human-associated microbes has expanded beyond that of
a few species toward an appreciation of the diverse and niche-specialized microbial …

The gut microbiota in the first decade of life

M Derrien, AS Alvarez, WM de Vos - Trends in microbiology, 2019 - cell.com
Appreciation of the importance of the gut microbiome is growing, and it is becoming
increasingly relevant to identify preventive or therapeutic solutions targeting it. The …

[HTML][HTML] Developmental trajectory of the healthy human gut microbiota during the first 5 years of life

J Roswall, LM Olsson, P Kovatcheva-Datchary… - Cell host & …, 2021 - cell.com
The gut is inhabited by a densely populated ecosystem, the gut microbiota, that is
established at birth. However, the succession by which different bacteria are incorporated …

Roles for intestinal bacteria, viruses, and fungi in pathogenesis of inflammatory bowel diseases and therapeutic approaches

RB Sartor, GD Wu - Gastroenterology, 2017 - Elsevier
Intestinal microbiota are involved in the pathogenesis of Crohn's disease, ulcerative colitis,
and pouchitis. We review the mechanisms by which these gut bacteria, fungi, and viruses …

Regulation of inflammation by microbiota interactions with the host

JM Blander, RS Longman, ID Iliev, GF Sonnenberg… - Nature …, 2017 - nature.com
The study of the intestinal microbiota has begun to shift from cataloging individual members
of the commensal community to understanding their contributions to the physiology of the …

A causal mechanism for childhood acute lymphoblastic leukaemia

M Greaves - Nature Reviews Cancer, 2018 - nature.com
In this Review, I present evidence supporting a multifactorial causation of childhood acute
lymphoblastic leukaemia (ALL), a major subtype of paediatric cancer. ALL evolves in two …

Personalized map** of drug metabolism by the human gut microbiome

B Javdan, JG Lopez, P Chankhamjon, YCJ Lee, R Hull… - Cell, 2020 - cell.com
The human gut microbiome harbors hundreds of bacterial species with diverse biochemical
capabilities. Dozens of drugs have been shown to be metabolized by single isolates from …

Healthy infants harbor intestinal bacteria that protect against food allergy

T Feehley, CH Plunkett, R Bao, SM Choi Hong… - Nature medicine, 2019 - nature.com
There has been a striking generational increase in life-threatening food allergies in
Westernized societies,. One hypothesis to explain this rising prevalence is that twenty-first …

Infant gut microbiome associated with cognitive development

AL Carlson, K **a, MA Azcarate-Peril, BD Goldman… - Biological …, 2018 - Elsevier
Background Studies in rodents provide compelling evidence that microorganisms inhabiting
the gut influence neurodevelopment. In particular, experimental manipulations that alter …

Effects of microbiota-directed foods in gnotobiotic animals and undernourished children

JL Gehrig, S Venkatesh, HW Chang, MC Hibberd… - Science, 2019 - science.org
INTRODUCTION There is a dimension to postnatal human development that involves
assembly of microbial communities in different body habitats, including the gut. Children with …