Multi-omics profiling for health

M Babu, M Snyder - Molecular & Cellular Proteomics, 2023 - ASBMB
The world has witnessed a steady rise in both non-infectious and infectious chronic
diseases, prompting a cross-disciplinary approach to understand and treating disease …

Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities

KD Davis, N Aghaeepour, AH Ahn, MS Angst… - Nature Reviews …, 2020 - nature.com
Pain medication plays an important role in the treatment of acute and chronic pain
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …

Guidelines for the use of flow cytometry and cell sorting in immunological studies

A Cossarizza, HD Chang, A Radbruch… - European journal of …, 2019 - Wiley Online Library
These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …

Multi-omics integration in biomedical research–A metabolomics-centric review

MA Wörheide, J Krumsiek, G Kastenmüller… - Analytica chimica …, 2021 - Elsevier
Recent advances in high-throughput technologies have enabled the profiling of multiple
layers of a biological system, including DNA sequence data (genomics), RNA expression …

Integrated trajectories of the maternal metabolome, proteome, and immunome predict labor onset

IA Stelzer, MS Ghaemi, X Han, K Ando… - Science translational …, 2021 - science.org
Estimating the time of delivery is of high clinical importance because pre-and postterm
deviations are associated with complications for the mother and her offspring. However …

Immune monitoring using mass cytometry and related high-dimensional imaging approaches

FJ Hartmann, SC Bendall - Nature Reviews Rheumatology, 2020 - nature.com
The cellular complexity and functional diversity of the human immune system necessitate the
use of high-dimensional single-cell tools to uncover its role in multifaceted diseases such as …

Holo-omics for deciphering plant-microbiome interactions

L Xu, G Pierroz, HML Wipf, C Gao, JW Taylor… - Microbiome, 2021 - Springer
Host-microbiome interactions are recognized for their importance to host health. An
improved understanding of the molecular underpinnings of host-microbiome relationships …

Multi-omics approaches in psychoneuroimmunology and health research: conceptual considerations and methodological recommendations

S Mengelkoch, SMSF Rose, Z Lautman, JC Alley… - Brain, Behavior, and …, 2023 - Elsevier
The field of psychoneuroimmunology (PNI) has grown substantially in both relevance and
prominence over the past 40 years. Notwithstanding its impressive trajectory, a majority of …

[HTML][HTML] A single-cell atlas of the myometrium in human parturition

R Pique-Regi, R Romero, V Garcia-Flores… - JCI insight, 2022 - ncbi.nlm.nih.gov
Parturition is a well-orchestrated process characterized by increased uterine contractility,
cervical ripening, and activation of the chorioamniotic membranes; yet, the transition from a …

Monocytes and macrophages in pregnancy: The good, the bad, and the ugly

H True, M Blanton, S Sureshchandra… - Immunological …, 2022 - Wiley Online Library
A successful human pregnancy requires precisely timed adaptations by the maternal
immune system to support fetal growth while simultaneously protecting mother and fetus …