Discovery and validation of biomarkers to aid the development of safe and effective pain therapeutics: challenges and opportunities
Pain medication plays an important role in the treatment of acute and chronic pain
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …
conditions, but some drugs, opioids in particular, have been overprescribed or prescribed …
Guidelines for the use of flow cytometry and cell sorting in immunological studies
These guidelines are a consensus work of a considerable number of members of the
immunology and flow cytometry community. They provide the theory and key practical …
immunology and flow cytometry community. They provide the theory and key practical …
Multi-omics integration in biomedical research–A metabolomics-centric review
Recent advances in high-throughput technologies have enabled the profiling of multiple
layers of a biological system, including DNA sequence data (genomics), RNA expression …
layers of a biological system, including DNA sequence data (genomics), RNA expression …
Integrated trajectories of the maternal metabolome, proteome, and immunome predict labor onset
Estimating the time of delivery is of high clinical importance because pre-and postterm
deviations are associated with complications for the mother and her offspring. However …
deviations are associated with complications for the mother and her offspring. However …
Immune monitoring using mass cytometry and related high-dimensional imaging approaches
The cellular complexity and functional diversity of the human immune system necessitate the
use of high-dimensional single-cell tools to uncover its role in multifaceted diseases such as …
use of high-dimensional single-cell tools to uncover its role in multifaceted diseases such as …
Holo-omics for deciphering plant-microbiome interactions
Host-microbiome interactions are recognized for their importance to host health. An
improved understanding of the molecular underpinnings of host-microbiome relationships …
improved understanding of the molecular underpinnings of host-microbiome relationships …
Multi-omics approaches in psychoneuroimmunology and health research: conceptual considerations and methodological recommendations
The field of psychoneuroimmunology (PNI) has grown substantially in both relevance and
prominence over the past 40 years. Notwithstanding its impressive trajectory, a majority of …
prominence over the past 40 years. Notwithstanding its impressive trajectory, a majority of …
[HTML][HTML] A single-cell atlas of the myometrium in human parturition
Parturition is a well-orchestrated process characterized by increased uterine contractility,
cervical ripening, and activation of the chorioamniotic membranes; yet, the transition from a …
cervical ripening, and activation of the chorioamniotic membranes; yet, the transition from a …
Monocytes and macrophages in pregnancy: The good, the bad, and the ugly
A successful human pregnancy requires precisely timed adaptations by the maternal
immune system to support fetal growth while simultaneously protecting mother and fetus …
immune system to support fetal growth while simultaneously protecting mother and fetus …