Nitrogen containing heterocycles as anticancer agents: a medicinal chemistry perspective
Cancer is one of the major healthcare challenges across the globe. Several anticancer
drugs are available on the market but they either lack specificity or have poor safety, severe …
drugs are available on the market but they either lack specificity or have poor safety, severe …
Concept of hybrid drugs and recent advancements in anticancer hybrids
Cancer is a complex disease, and its treatment is a big challenge, with variable efficacy of
conventional anticancer drugs. A two-drug cocktail hybrid approach is a potential strategy in …
conventional anticancer drugs. A two-drug cocktail hybrid approach is a potential strategy in …
Pyrimidine: a review on anticancer activity with key emphasis on SAR
A Mahapatra, T Prasad, T Sharma - Future journal of pharmaceutical …, 2021 - Springer
Background Cancer is a global health challenge, it impacts the quality of life and its
treatment is associated with several side effects. Resistance of the cancer cells to the …
treatment is associated with several side effects. Resistance of the cancer cells to the …
Therapeutic potential of heterocyclic pyrimidine scaffolds
S Kumar, B Narasimhan - Chemistry Central Journal, 2018 - Springer
Heterocyclic compounds offer a high degree of structural diversity and have proven to be
broadly and economically useful as therapeutic agents. Comprehensive research on diverse …
broadly and economically useful as therapeutic agents. Comprehensive research on diverse …
Synthesis of novel pyrido [2, 3-d] pyrimidine-thiazolidine-1, 2, 3-triazoles: Potent EGFR targeting anticancer agents
In this study, we designed and synthesized a number of novel pyrido [2, 3-d] pyrimidine-
thiazolidine-1, 2, 3-triazole derivatives and investigated them in vitro for their inhibitory …
thiazolidine-1, 2, 3-triazole derivatives and investigated them in vitro for their inhibitory …
Synthetic chemistry of pyrimidines and fused pyrimidines: A review
S Mohana Roopan, R Sompalle - Synthetic Communications, 2016 - Taylor & Francis
This review is an attempt to compile the literature of various synthetic procedures of
pyrimidine analogs. Pyrimidine and its fused pyrimidine derivatives are a class of …
pyrimidine analogs. Pyrimidine and its fused pyrimidine derivatives are a class of …
Synthesis of novel 1, 2, 3-triazole substituted-N-alkyl/aryl nitrone derivatives, their anti-inflammatory and anticancer activity
PS Rao, C Kurumurthy, B Veeraswamy… - European Journal of …, 2014 - Elsevier
Abstract A series of novel 1, 2, 3-triazole substituted N-phenyl nitrone derivatives 5a–e were
prepared in three steps starting from 1-substituted-1, 2, 3-triazole-4-carbaldehydes 2 via …
prepared in three steps starting from 1-substituted-1, 2, 3-triazole-4-carbaldehydes 2 via …
Have molecular hybrids delivered effective anti-cancer treatments and what should future drug discovery focus on?
Shalini, V Kumar - Expert Opinion on Drug Discovery, 2021 - Taylor & Francis
Introduction Cancer continues to be a big threat and its treatment is a huge challenge
among the medical fraternity. Conventional anti-cancer agents are losing their efficiency …
among the medical fraternity. Conventional anti-cancer agents are losing their efficiency …
A convenient catalytic method for preparation of new tetrahydropyrido [2, 3-d] pyrimidines via a cooperative vinylogous anomeric based oxidation
In this study, a novel functionalized metal–organic frameworks MIL-125 (Ti)-N (CH2PO3H2)
2 was designed and synthesized via post-modification methodology. Then, MIL-125 (Ti)-N …
2 was designed and synthesized via post-modification methodology. Then, MIL-125 (Ti)-N …
Nitrogen-fused heterocycles: Empowering anticancer drug discovery
The worldwide impact of cancer is further compounded by the constraints of current
anticancer medications, which frequently exhibit a lack of selectivity, raise safety …
anticancer medications, which frequently exhibit a lack of selectivity, raise safety …