Nitrogen containing heterocycles as anticancer agents: a medicinal chemistry perspective

A Kumar, AK Singh, H Singh, V Vijayan, D Kumar… - Pharmaceuticals, 2023 - mdpi.com
Cancer is one of the major healthcare challenges across the globe. Several anticancer
drugs are available on the market but they either lack specificity or have poor safety, severe …

Concept of hybrid drugs and recent advancements in anticancer hybrids

AK Singh, A Kumar, H Singh, P Sonawane, H Paliwal… - Pharmaceuticals, 2022 - mdpi.com
Cancer is a complex disease, and its treatment is a big challenge, with variable efficacy of
conventional anticancer drugs. A two-drug cocktail hybrid approach is a potential strategy in …

Pyrimidine: a review on anticancer activity with key emphasis on SAR

A Mahapatra, T Prasad, T Sharma - Future journal of pharmaceutical …, 2021 - Springer
Background Cancer is a global health challenge, it impacts the quality of life and its
treatment is associated with several side effects. Resistance of the cancer cells to the …

Therapeutic potential of heterocyclic pyrimidine scaffolds

S Kumar, B Narasimhan - Chemistry Central Journal, 2018 - Springer
Heterocyclic compounds offer a high degree of structural diversity and have proven to be
broadly and economically useful as therapeutic agents. Comprehensive research on diverse …

Synthesis of novel pyrido [2, 3-d] pyrimidine-thiazolidine-1, 2, 3-triazoles: Potent EGFR targeting anticancer agents

SR Bandi, R Kapavarapu, R Palabindela… - Journal of Molecular …, 2023 - Elsevier
In this study, we designed and synthesized a number of novel pyrido [2, 3-d] pyrimidine-
thiazolidine-1, 2, 3-triazole derivatives and investigated them in vitro for their inhibitory …

Synthetic chemistry of pyrimidines and fused pyrimidines: A review

S Mohana Roopan, R Sompalle - Synthetic Communications, 2016 - Taylor & Francis
This review is an attempt to compile the literature of various synthetic procedures of
pyrimidine analogs. Pyrimidine and its fused pyrimidine derivatives are a class of …

Synthesis of novel 1, 2, 3-triazole substituted-N-alkyl/aryl nitrone derivatives, their anti-inflammatory and anticancer activity

PS Rao, C Kurumurthy, B Veeraswamy… - European Journal of …, 2014 - Elsevier
Abstract A series of novel 1, 2, 3-triazole substituted N-phenyl nitrone derivatives 5a–e were
prepared in three steps starting from 1-substituted-1, 2, 3-triazole-4-carbaldehydes 2 via …

Have molecular hybrids delivered effective anti-cancer treatments and what should future drug discovery focus on?

Shalini, V Kumar - Expert Opinion on Drug Discovery, 2021 - Taylor & Francis
Introduction Cancer continues to be a big threat and its treatment is a huge challenge
among the medical fraternity. Conventional anti-cancer agents are losing their efficiency …

A convenient catalytic method for preparation of new tetrahydropyrido [2, 3-d] pyrimidines via a cooperative vinylogous anomeric based oxidation

H Sepehrmansourie, S Kalhor, M Zarei, MA Zolfigol… - RSC …, 2022 - pubs.rsc.org
In this study, a novel functionalized metal–organic frameworks MIL-125 (Ti)-N (CH2PO3H2)
2 was designed and synthesized via post-modification methodology. Then, MIL-125 (Ti)-N …

Nitrogen-fused heterocycles: Empowering anticancer drug discovery

T Biswas, RK Mittal, V Sharma, Kanupriya… - Medicinal …, 2024 - benthamdirect.com
The worldwide impact of cancer is further compounded by the constraints of current
anticancer medications, which frequently exhibit a lack of selectivity, raise safety …