Dipeptidyl-peptidase 4 (DPP4) is a glycoprotein of 110 kDa, which is ubiquitously expressed
on the surface of a variety of cells. This exopeptidase selectively cleaves N-terminal …

The maintenance of normal glucose homeostasis requires a complex, highly integrated
interaction among the liver, muscle, adipocytes, pancreas and neuroendocrine system …

OBJECTIVE—This study evaluated the effects of exenatide, a novel incretin mimetic, in
hyperglycemic patients with type 2 diabetes unable to achieve glycemic control with …

Insulin and glucagon are potent regulators of glucose metabolism. For decades, we have
viewed diabetes from a bi-hormonal perspective of glucose regulation. This perspective is …

The prevalence of type 2 diabetes is increasing at an astounding rate. Many of the agents
used to treat type 2 diabetes have undesirable adverse effects of hypoglycemia and weight …

Efforts to further elucidate structure− activity relationships (SAR) within our previously
disclosed series of β-quaternary amino acid linked l-cis-4, 5-methanoprolinenitrile dipeptidyl …

Background: Physicians may use either insulin or exenatide injections for patients with type
2 diabetes mellitus who have poor glycemic control despite taking oral blood glucose …

There is a progressive deterioration in β-cell function and mass in type 2 diabetics. It was
found that islet function was about 50% of normal at the time of diagnosis, and a reduction in …

Alzheimer disease (AD) is the most common form of dementia among the elderly and is
characterized by progressive loss of memory and cognition. Epidemiological data show that …

Metabolic syndrome (MetS) is a cluster of cardiovascular risk factors that includes obesity,
diabetes, and dyslipidemia. Accumulating evidence implies that MetS contributes to the …